Brain Cancer

Brain and Other Central Nervous System Cancers: Recent Trends in Incidence and Mortality Authors: Julie M. Legler, Lynn A. Gloeckler Ries, Malsolm A. Smith, et al. Source: Journal of the National Cancer Institute, Volume 91, No 16 (August): 1382-1390, 1999This study was based on data obtained from the Surveillance, Epidemiology, and End...
Brain Metastases in Patients with No Known Primary Tumor Authors: Satoshi Maesawa, Douglas Kondziolka, Todd P. Thompson, et al. Source: Cancer 89:1095-1101, (September) 2000IntroductionBrain metastases are a common complication in cancer patients and an important cause of morbidity and mortality. In...
Brain metastases treated with radiosurgery alone: An alternative to whole brain radiotherapy? Authors: Hasegawa T, Kondziolka D, Flickinger JC, Germanwala A, Lunsford LD Source: Neurosurgery June 2003; 52(6): 1318-26 Background The incidence of brain metastases as a result of systemic cancer is 20-40%. Many cases are identified in...
Chemotherapy for Brain Tumors Authors: Irene V. Pech, MD, PhD, Neuro-Oncology Fellow, Department of Neurology and Neurological Sciences; Kendra Peterson, MD Source: Oncology, April 1998, Volume 12, Number 4, pages 537-547 IntroductionThe treatment of adults and children with...
High Incidence of Secondary Brain Tumours After Radiotherapy and Antimetabolites Authors: Relling MV, et al. Source: Lancet 1999; Volume 354: pages 34 - 39BackgroundSt. Jude Children's Research Hospital has published an early report of their data from Total XII protocol regarding secondary brain tumors in patients treated with...
Long-Term Outcomes after Radiosurgery for Acoustic Neuromas Authors: Douglas Kondziolka, L. Dade Lunsford, Mark R. McLaughlin, John C. Flickinger Source: New England Journal of Medicine, November 12, 1998, Vol. 339 No. 20 p1426BackgroundAcoustic neuromas are benign tumors that arise along the eighth cranial...
Outcome in elderly patients undergoing definitive surgery and radiation therapy for supratentorial glioblastoma multiforme at a tertiary care institution Authors: Mohan, DS et al Source: International Journal of Radiation Oncology, Biology and Physics Vol. 42 No. 5 p.981, December 1, 1998BackgroundThe treatment of elderly patients with glioblastoma is controversial. In light of the poor prognosis...
Prognostic Value of Initial Magnetic Resonance Imaging Growth Rates for World Health Organization Grade II Glioma Author: Pallud J. et al Source: Ann Neurol 2006;60:380-383 Objective To determine if MRI-based measurement of growth rate prior to treatment has prognostic value in grade II gliomas. Methods 143 consecutive patients diagnosed between...
Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma Authors: Stupp R, Mason WP, van den Bent MJ et al NEJM, March 10 2005;352:10, pp 987-996 Introduction Glioblastoma multiforme is the most common primary malignant brain tumor in adults and carries a median survival of less than 1 year. ...
Randomized Trial on the efficacy of Radiotherapy for Cerebral Low-Grade Glioma in the Adult: European Organization for Research and Treatment of Cancer Study 22845 with the Medical Research Council Study BR04: An Interim Analysis Authors: Karim et al. Source: Int. J. Radiation Oncology Biol. Phys., Vol. 52, No. 2 pp. 316-32, 2002 Introduction There is no consensus on the treatment strategy for adult patients with cerebral low-grade glioma. The diagnosis and primary...
Stereotactic Radiosurgery in the Treatment of Metastatic Disease to the Brain Authors: Joseph C.T. Chen, Zbigniew Petrovich, Steven O'Day, et al. Source: Neurosurgery, Volume 47:268-281, (August) 2000IntroductionWhole brain radiation therapy (WBRT) has been the standard care for the majority of patients with brain...
Survival benefit of hyperthermia in a prospective randomized trial of brachytherapy boost +/- hyperthermia for glioblastoma multiforme Authors: Sneed PK, Stauffer PR, McDermott MW, et. al. Source: International Journal of Radiation Oncology, Biology and Physics, 15 January 1998, Volume 40 number 2 p287Glioblastomas are among the most aggressive of human cancers. These tumors of the...
The risk of hemorrhage after radiosurgery for cerebral arteriovenous malformations Authors: Maruyama K, Kawahara N, Shin M, Tago M, Kishimoto J, Kurita H, Kawamoto S, Morita A, Kirino T. Source: New England Journal of Medicine, 352(2); 146-153, 2005. Background Arteriovenous malformations (AVMs) are defined by the...
Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial Authors: Andrews DW, Scott CB, Sperduto PW, Flanders AE, Gaspar LE, Schell MC, Werner-Wasik M, Demas W, Ryu J, Bahary JP, Souhami L, Rotman M, Mehta MP, Curran WJ, RTOG Source: Lancet 2004 May 22; 363: 1665-72 Background As many as 20-40% of cancer...