Colorectal Cancer

5-Fluorouracil-Induced Small Bowel Toxicity in Patients with Colorectal Carcinoma Reviewers: Li Liu, MD Source: Cancer, Volume 86, No 7:1129-1134, October 1999.Background5-fluorouracil (5-FU) is used in the treatment of a variety of human malignancies either as single agent therapy or in combination with other antitumor agents....
A Comparison of Colonoscopy and Double-Contrast Barium Enema for Surveillance after Polypectomy Reviewers: Li Liu, M.D Source: New England Journal of Medicine Volume 342 (24), 1766-1772 (June) 2000Précis: Colonoscopy is superior to barium enema for postpolypectomy surveillance.IntroductionIt is widely held that adenomatous polyps are...
Adverse effects of preoperative radiation therapy for rectal cancer: long-term follow-up of the Swedish rectal cancer trial Birgisson H, Pahlman L, Gunnarsson U, Glimelius B. Journal of Clinical Oncology 23:8697-8705, 2005. Introduction Radiation therapy and/or chemotherapy combined with surgery typically comprise the standard treatment for early to intermediate...
Colorectal Cancer Screening and Surveillance Practices by Primary Care Physicians: Results of a National Survey Reviewers: Li Liu, MD Source: The American Journal of Gastroenterology, Volume 95:1551-1556, (June) 2000.Précis: Colorectal cancer screening by many primary physicians may not be adequateIntroductionThe American Cancer Society and the...
Conservative treatment of Rectal Adenocarcinoma with Endocavitary Irradiation or Wide Local Excision and Postoperative Irradiation Reviewers: John Han-Chih Chang, M.D. and Kenneth Blank, M.D. Source: Journal of Clinical Oncology October 1997, Volume 15: pp 3241 - 8. BackgroundAlong with cure of the disease, sphincter (anal) preservation is an ultimate goal in the treatment in...
Cost-Effectiveness of Colonoscopy in Screening for Colorectal Cancer Reviewers: Li Liu, MD Source: Annals of Internal Medicine, Volume 133:573-584, (October) 2000Précis: Colonoscopy is favored for colorectal cancer screeningIntroductionColorectal cancer is the second leading cause of death in North America....
Dietary fiber and the risk of colorectal cancer and adenoma in women Reviewers: Kenneth Blank, MD Source: The New England Journal of the Medicine, January 21, 1999, Vol. 340 No. 3 p.169BackgroundAs we enter the final year of the 20th century, a look back reveals amazing strides in medicine: the advent of...
Fecal Occult Blood Screening in the Minnesota Study: Role of Chance Detection of Lesions Reviewers: Leonard A. Farber, M.D. and John Chang, M.D. Source: Journal of the National Cancer Institute 1997;89:1423-8 In the past, randomized trials have found that the mortality from colorectal cancer is reduced by periodic fecal occult blood...
Guanylyl Cyclase C Messenger RNA is a Biomarker for Recurrent Stage II Colorectal Cancer Reviewers: Li Liu, MD Source: Annals of Internal Medicine, 131(11): 805-812, December 1999.Précis: In this study, expression of guanylyl cyclase C mRNA appeared to be strongly associated with the presence of colorectal cancer micrometastases...
Impact of a Clinical Guidelines Program for Breast and Colon Cancer in a French Cancer Center Reviewers: John Han-Chih Chang, MD and Kenneth Blank, MD Source: The Journal of the American Medical Association 1997; Volume 278: pages 1591 - 95BackgroundIn most European countries, medical (especially cancer) care isusually centralized in a few...
Incidence of Hereditary Nonpolyposis Colorectal Cancer and the Feasibility of Molecular Screening for the Disease Reviewers: Kenneth Blank, MD and John Han-Chih Chang, MD Source: The New England Journal of Medicine, Volume 338 (21):1481Hereditary non-polyposis colorectal cancer (HNPCC) is a genetic disorder which, predisposes people to colon and other...
Influence of the Interval Between Preoperative Radiation Therapy and Surgery on Downstaging and on the Rate of Sphincter-Sparing Surgery for Rectal Cancer: The Lyon R90-01 Randomized Trial Reviewers: John Han-Chih Chang, MDSource: Journal of Clinical Oncology Volume 17 (Number 8): pages 2396 - 2402BackgroundThere will be 56,000 colorectal cancers in the US in 1999. It remains the third leading cause of cancer deaths nationwide. ...
Multicenter Phase II Study to Evaluate a 28-Day Regimen of Oral Fluorouracil Plus Eniluracil in the Treatment of Patients with Previously Untreated Metastatic Colorectal Cancer Reviewers: Li Liu, MD Source: Journal of Clinical Oncology, Volume 18:2894-2901, (August) 2000Précis: Oral fluorouracil plus eniluracil is effective in treating metastatic colon cancerIntroductionFluorouracil (5-FU) has been a mainstay of...
Preoperative versus Postoperative Chemoradiotherapy for Rectal Cancer Authors: Rolf Sauer MD, Heinz Becker MD, Werner Hohenberger MD, et al. for the German Rectal Cancer Study Group Source: New England Journal of Medicine 351(17): 1731-1340 (2004) Background Adjuvant radiotherapy (RT) with or without...
Tumor Downstaging and Sphincter Preservation with Preoperative Chemoradiation in Locally advanced rectal cancer: The M. D. Anderson Cancer Center Experience Reviewers: Li Liu, MD Source: International Journal of Radiation Oncology, Biology, and Physics, Volume 44, No 5 (July): 1027-1038, 1999.BackgroundNutritional support has long been known as an important part of multimodality treatment of head and...
Use of Colonoscopy to Screen Asymptomatic Adults for Colorectal Cancer Reviewers: Li Liu, MD Source: New England Journal of Medicine, Volume 343(14): 162-168, (July) 2000.Précis: Colonoscopy is favored for colorectal cancer screening in asymptomatic adultsIntroductionAlmost all colorectal cancers arise from...