Head and Neck Cancers

A Phase I Trial of 96-Hour Paclitaxel Infusion Plus Accelerated Radiotherapy for Unresectable Head and Neck Cancer Reviewers: John Han-Chih Chang, MD Source: International Journal of Radiation Oncology Biology and Physics 1999; Volume 44: pages 311 - 315.BackgroundThis phase I study addresses the question of the maximum tolerated dose (MTD) when Taxol is...
An Intergroup Phase III Comparison of Standard Radiation Therapy and Two Schedules of Concurrent Chemoradiotherapy in Patients With Unresectable Squamous Cell Head and Neck Cancer Authors: Adelstein D, Li Y, Adams G, et al. Source: Journal of Clinical Oncology 2003; 21 (1): 92-98 Background Radiotherapy (RT) is the standard of care for unresectable squamous cell carcinomas of the Head and Neck, but the overall survival...
Chemoradiotherapy versus Radiotherapy in Patients with Advanced Nasopharyngeal Cancer: Phase III Randomized Intergroup Study 0099 Reviewers: John Han-Chih Chang, MD and Kenneth Blank, MD Source: Journal of Clinical Oncology, Volume 16 Number 4, pg. 1310-1317BackgroundNasopharyngeal carcinomas are rare entities in the United States and comprise less than 1% of all...
Chemoradiotherapy Versus Radiotherapy in Patients With Advanced Nasopharyngeal Cancer: Phase III Randomized Intergroup Study 0099 Reviewers: Li Liu, MD Source: Journal of Clinical Oncology, Volume 16, No 4 (April), 1998BackgroundThe nasopharynx is a cubical cavity located behind the nasal cavity and superior to the soft palate. Superiorly it borders the base of skull and...
Evidence for a Causal Association Between Human Papillomavirus and a subset of Head and Neck Cancers Reviewers: Li Liu, MD Source: Journal of the National cancer Institute, Vol. 92, No 9, 709-720, (May) 2000Précis: Association of human papillomaviruses with some head and neck squamous cell cancers.IntroductionHuman papillomaviruses (HPVs)...
Hyperfractionated Irradiation with or without Concurrent Chemotherapy for Locally Advanced Head and Neck Cancer Source: The New England Journal of Medicine Vol 338(25): 1798-1804, 1998 Author: Brizel, David M. et al Affiliation: Departments of Radiation Oncology, Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, N.C. Background ...
Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer Authors: Wolf, G.T. et al. (The Department of Veterans Affairs (VA) Laryngeal Cancer Study Group) Source: NEJM. 1991 324(24):1685-90. Affiliation: Ann Arbor VA Medical Center, Ann Arbor, MI. Background Prior to this landmark study,...
Phase III Study of Concurrent Chemoradiotherapy versus Radiotherapy Alone for Advanced Nasopharyngeal Carcinoma: Positive Effect on Overall and Progression-Free Survival Authors: Lin J, Jan J, Hsu C, Liang W, Jiang R, Wang W Source: Journal of Clinical Oncology, 2003; 21:4, 631-637. Background Nasopharyngeal carcinoma (NPC) is much more commonly seen in Southeast Asian, North African, and Eskimo populations...
Postoperative Concurrent Radiotherapy and Chemotherapy for High-Risk Squamous-Cell Carcinoma of the Head and Neck, RTOG 9501/Intergroup Source: N Engl J Med. 2004 May 6;350(19):1937-44 Introduction Combined chemotherapy and radiation has become a well-accepted treatment for unresectable or locally advanced head and neck cancer, due to the findings from several large clinical...
Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer Authors: Bernier J, Domenge C, Ozsahin M, Matuszewska K, Lefebvre JL, Greiner RH, Giralt J, Maingon P, Rolland F, Bolla M, Cognetti F, Bourhis J, Kirkpatrick A, van Glabbeke M Source: N Engl J Med. 2004 May 6;350(19):1945-52. Background In...
Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group Authors: Lee AW, Lau WH, Tung SY, Chua DT, Chappell R, Xu L, Siu L, Sze WM, Leung TW, Sham JS, Ngan RK, Law SC, Yau TK, Au JS, O'Sullivan B, Pang ES, O SK, Au GK, Lau JT; Hong Kong Nasopharyngeal Cancer Study Group. Source: J Clin Oncol. 2005 Oct...
Preradiotherapy Computed Tomography as a Predictor for Local Control in Supraglottic Carcinoma Reviewers: Kenneth Blank, MD Source: Journal of Clinical Oncology Vol 17, No 2 p 631 1999IntroductionSuccessful treatment of supraglottic carcinoma can be achieved with either surgery or radiotherapy. Historically, patients with small tumors...
Recurrences after Conformal Parotid-Sparing Radiotherapy Source: Radiotherapy and Oncology 72 (2004) 119-127 Authors: Barbara Bussels, Annelies Maes, Robert Hermans, Sandra Nuyts, Caroline Weltens, Walter Van den Bogaert Background One of the most difficult long-term complications of radiation...
Simultaneous Radiochemotherapy versus Radiotherapy Alone in Advanced Head and Neck Cancer: a Randomized Multi-center Study Reviewers: John Han-Chih Chang, MD and Kenneth Blank, MD Source: Journal of Clinical Oncology 1998; Volume 16 (Number 4): pages 1318 ? 1324. BackgroundHead and Neck cancer is a heterogeneous group of malignancies. This article addressed a wide...
The Impact of Nutritional Status on the Prognoses of Patients with Advanced Head and Neck Cancer Reviewers: Li Liu, MD Source: Cancer, Volume 86, No 3 (August): 519-527, 1999.BackgroundNutritional support has long been known as an important part of multimodality treatment of head and neck cancer. Radiation therapy, chemotherapy, and surgery...