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A controlled Study of Postoperative Radiotherapy for Patients with Completey Resected Non-Small Cell Lung Carcinoma
Reviewers: John Han-Chih Chang, MD Source: Cancer 1999 Jul 15; Volume 86(Number 2): pages 265 - 273Background/Critique/DiscussionOverall, non-small cell lung cancer (NSCLCa) comprises about 85% of the 171,000 newly diagnosed lung cancers each... |
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Chemoradiation for Locally Advanced, Unresectable NSCLC-New Standard of Care, Emerging Strategies
Reviewers: Li Liu, MDSource: Oncology, 13:1075-1088, August 1999BackgroundThis comprehensive review of the management of locally advanced unresectable non-small-cell lung cancer (NSCLC) summarizes major landmark studies that have led to the current... |
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Molecular Pathological Substaging in 244 Stage I Non-Small Cell Lung Cancer Patients: Clinical Implications
Reviewers: John Han-Chih Chang, MD and Kenneth Blank, MD Source: Journal of Clinical Oncology 1998; volume 16 (number 7): pages 2468 ? 2477IntroductionNon-small cell lung cancer is one of the most deadly malignancies secondary to its high... |
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Multi-Institutional Randomized Phase II Trial of Gefitinib for Previously Treated Patients with Advanced Non-Small Cell Lung Cancer
Authors: Masahiro Fukuoka, Seiji Yano, Giuseppe Giaccone, Tomohide Tamura, Kazuhiko Nakagawa, Jean-Yves Douillard, Yutaka Nishiwaki, Johan Vansteenkiste, Shinzoh Kudoh, Danny Rischin, Richard Eek, Takeshi Horai, Kazumasa Noda, Ichiro Takata, Egbert... |
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Patterns of Failure after Resection of Non-small-cell lung cancer: Implications for Postoperative Radiation Therapy Volumes
Authors: Kelsey CR, Light KL, Marks LB Reference: Int J Radiat Oncol Biol Phys. 2006 Jul 15;65(4):1097-105 Affiliation: Department of Radiation Oncology, Duke University Medical Center Background Several studies have shown that local... |
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Phase III Study of Concurrent versus Sequential Thoracic Radiotherapy in Combination with Mitomycin, Vindesine, and Cisplatin in Unresectable Stage III Non-Small-Cell Lung cancer
Reviewers: Li Liu, MDSource: Journal of Clinical Oncology, 17(9): 2692, September 1999BackgroundThis is a long-term follow-up of a landmark study by the West Japan Lung Cancer Group (WJLCG) directly comparing concurrent chemoradiation to sequential... |
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Postoperative radiotherapy in non-small cell lung cancer: systematic review and meta-analysis of individual patient data from nine randomized controlled trials
Author: PORT Meta-analysis Trialists Group Source:Lancet. 1998 Jul 25;352(9124):257-63 Background Lung cancer remains the leading cause of cancer death in the United States. Surgery is the treatment of choice for non-small cell lung cancer... |
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Preoperative Chemotherapy Followed by Concurrent Chemoradiation Therapy Based Hyperfractionated Accelerated Radiotherapy and Definitive Surgery in Locally Advanced Non-Small Cell LungCancer: Mature Results of a Phase II Trial
Source Journal of Clinical Oncology 1998; Volume 16 (Number 2): pages 622-634.BackgroundLocally advanced non-small cell lung cancer (NSCLCa) has a very poor prognosis. By the American Joint Committee on Cancer, the stages included in the definition... |
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Prospective Randomized Trial of Docetaxel Versus Best Supportive Care in Patients With Non?Small-Cell Lung Cancer Previously Treated With Platinum-Based Chemotherapy
Reviewers: Li Liu, MDSource: Journal of Clinical Oncology, Vol 18, Issue 10 (May), 2000: 2095-2103IntroductionLung cancer is the leading cause of death from cancer for both men and women in the United States and accounts for approximately 14% of new... |
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Radiosensitization with Carboplatin for Patients with Unresectable Stage III Non-Small-Cell Lung Cancer: A phase III Trial of the Cancer and Leukemia Group B and the Eastern Cooperative Oncology Group
Reviewers: John Han-Chih Chang, MDSource: Journal of Clinical Oncology 1999; Volume 17 (Number 1): pages 4 ? 11BackgroundNon-small-cell lung cancer (NSCLCa) is usually best treated with surgery as the mainstay of curative therapy, reserving... |
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Randomized Phase III Study of Gemcitabine-Cisplatin Versus Etoposide-Cisplatin in the Treatment of Locally Advanced or Metastatic Non-Small-Cell Lung Cancer
Reviewers: John Han-Chih Chang, MDSource: Journal of Clinical Oncology 1999; Volume 17: pages 12 ? 18BackgroundChemotherapy (ChT) for advanced non-small-cell lung cancer (NSCLCa) has been a fairly controversial topic for many years. There have been... |
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Randomized Phase III Trial of Docetaxel Versus Vinorelbine or Ifosfamide in Patients With Advanced Non?Small-Cell Lung Cancer Previously Treated With Platinum-Containing Chemotherapy Regimens
Source: Journal of Clinical Oncology, Vol 18, Issue 12 (June), 2000: 2354-2362IntroductionNon-small cell lung cancer (NSCLC) is a leading cause of deaths related to cancer. Surgery is the treatment of choice, but only about 20% of tumors are... |
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Toxicity and Outcome Results of RTOG 93-11: A Phase I-II Dose-Escalation Study Using Three-Dimensional Conformal Radiotherapy in Patients with Inoperable Non-small-cell Lung Carcinoma
Background The RTOG (Radiation Therapy Oncology Group) initiated dose escalation protocol 93-11 for patients with stage I-III lung cancer in order to attempt improvement in local control. Three-dimensional conformal radiotherapy was used to... |