Pediatric Cancers

Change in Neurocognitive Functioning After Treatment with Cranial Radiation in Childhood Authors: BJ Spiegler, E Bouffet, ML Greenberg, et al. Source:Journal of Clinical Oncology 22 (2004) 706–713. Background Treatment of pediatric posterior fossa tumors has evolved in the multimodality setting to the...
Congestive Heart Failure After Treatment for Wilms' Tumor: A report from the National Wilms' Tumor Study Group Reviewers: Li Liu, MD Source: Journal of Clinical Oncology, Vol 19, Issue 7 (April), 2001: 1926-1934IntroductionThe prognosis for children with Wilms' tumor has improved dramatically during the past three decades. The purpose of this study was to...
Conventional Compared with Individualized Chemotherapy for Childhood Acute Lymphoblastic Leukemia Reviewers: Kenneth Blank, MD and Leonard Farber, MD Source: The New England Journal of Medicine --February 19, 1998 --Volume 338, Number 8The rate at which children clear anti-leukemic agents is highly variable. Rapid clearance of anti-leukemic...
Hemangiomas in Children Reviewers: Li Liu, MDSource: New England Journal of Medicine, 341:173-181, July 1999BackgroundThis is a comprehensive review of hemangiomas in children. It provides useful information regarding the pathogenesis, clinical manifestations,...
Impact of Radiotherapy for High-Risk Neuroblastoma: A Children's Cancer Group Study Authors: Haas Kogan DA, Swift PS, Selch M, et al. Source: Oncology Biol. Phys. , Vol. 56, pp. 28-39, 2003. Background Neuroblastoma strikes 650 children per year in the US Survival at 5 years remains <30% for high-risk tumors in...
Influence of a Child's Sex on Medulloblastoma Outcome Reviewers: Kenneth Blank, MD and Leonard Farber, MD Source: Journal of the American Medical Association, Vol 279, No. 18 Medulloblastoma is the most common brain tumor of childhood. Despite aggressive therapy with surgery, radiation and...
Long-Term Neurological Outcome of Childhood Brain Tumors Treated by Surgery Only Authors: Sonderkaer S, et al. Source: JCO, 21(7), 2003, pg 1347-1351 Background Intracranial tumors are common in pediatric patients, relative to other childhood malignancies The results have improved in...
Low-Stage Medulloblastoma: Final Analysis of Trial Comparing Standard-Dose With Reduced-Dose Neuraxis Irradiation Authors: Thomas PRM, Deutsch M, Kepner JL, et al. Source: Journal of Clinical Oncology, 18(16), 2000, pg 3004-3011 Background: Medulloblastoma is a primitive cerebellar tumor of neuroectodermal origin. It is a childhood malignancy (median...
Metastasis Stage, Adjuvant Treatment, and Residual Tumor Are Prognostic Factors for Medulloblastoma in Children: Conclusions From the Children's Cancer Group 921 Randomized Phase III Study Reviewers: John Han-Chih Chang, MD Source: Journal of Clinical Oncology 1999; Volume 17: pages 832 - 845BackgroundIn childhood, the most common tumor of the posterior fossa is a medulloblastoma (MB). Most arise in the cerebellar vermis andgrow...
Outcome of Radiation-Related Osteosarcoma after Treatment of Childhood and Adolescent Cancer: A Study of 23 Cases Reviewers: John Han-Chih Chang, MD Source: Journal of Clinical Oncology 1999; Volume 17: pages 2789 ? 2795BackgroundSurvival and control rates of pediatric malignancies have continued to rise over the past decades. While combinations of surgery,...
Randomized Comparison of Low-Dose Involved-Field Radiotherapy and No Radiotherapy for Children with Hodgkin's Disease Who Achieve a Complete Response to Chemotherapy Authors: Nachman JB, Sposto R, Herzog P, Gilchrist GS, Wolden SL, Thomson J, Kadin ME, Pattengale P, Davis PC, Hutchinson RJ, White K; Children's Cancer Group. Source: J Clin Oncol. 2002 Sep 15;20(18):3765-71 Background Standard therapy for...
Risk of cancer among offspring of childhood-cancer survivors Reviewers: Kenneth Blank, MD and John Han-Chih Chang, MD Source: New England Journal of Medicine, May 7, 1998 338 (19):1339The successful treatment of childhood cancers has substantially increased the number of cancer survivors who are interested...
Subsequent Quality of Life for Children Irradiated for a Brain Tumor Before Age Four Years Reviewers: John Han-Chih Chang, MD Source: Medical and Pediatric Oncology 1998; Volume 31: pages 506 - 511.BackgroundPrimary brain tumors are among the most common malignancy in the pediatric population. Historically, the patients have been...
Symptoms and Suffering at the End of Life in Children with Cancer Reviewers: Li Liu, MDSource: The New England Journal of Medicine, volume 342, 326-333, (February) 2000IntroductionOver the past 30 years, cure rates have increased dramatically for a number of pediatric malignancies because of scientific and...
Thyroid Carcinomas After Irradiation for a First Cancer During Childhood Reviewers: Li Liu, MD Source: Archives of Internal Medicine, 159(22): 2713-2719, December 1999.Précis: External beam radiotherapy (EBRT) during childhood is strongly associated with risk of developing thyroid carcinoma.IntroductionMany...
Treatment of Children and Young Adults with Early-Stage Non-Hodgkin's Lymphoma Reviewers: Kenneth Blank, M.D. and John Chang M.D. Source: The New England Journal of Medicine -- October 30, 1997 -- Volume 337, Number 18The treatment of children and young adults with early stage Non-Hodgkins lymphoma (NHL) has seen remarkable...