Cancer News
OncoLink Cancer News - HealthDay


Also, red meat intake and genetic variations may jointly influence bladder cancer susceptibility

-- Beth Gilbert

Tuesday, April 20, 2010 (Last Updated: 04/21/2010)

TUESDAY, April 20 (HealthDay News) -- Secondhand smoke, high consumption of red or fried meat, and certain genetic variants are associated with an increased risk of bladder cancer, according to the results of two studies presented at the annual meeting of the American Association for Cancer Research, held from April 17 to 21 in Washington, D.C.

Li Tao, M.D., of the University of Minnesota in Minneapolis, and colleagues studied 202 bladder cancer patients who were lifelong nonsmokers and 268 lifelong nonsmoking controls. They found that lifelong nonsmokers whose mothers smoked more than 10 pack-years had a 3.51-fold increased risk of bladder cancer compared to their lifelong nonsmoking counterparts who had never been exposed to secondhand smoke. Individuals sharing an office environment five or more hours per day with coworkers who smoked were at two-fold elevated risk of bladder cancer. However, the researchers found that CYP1A2 and NAT2 acetylation phenotypes exerted a moderate modifying effect on the association between secondhand smoke and bladder cancer.

In another study, Jie Lin, Ph.D., of the University of Texas M.D. Anderson Cancer Center in Houston, and colleagues evaluated 884 patients with confirmed bladder cancer and 878 healthy controls to determine the link between meat consumption, cooking methods, genetic predisposition and bladder cancer risk. They found that higher consumption of beef steaks, pork chops, bacon, fried chicken and fried fish, as well as consumption of meats cooked medium-well or well-done, were each associated with an increased risk of bladder cancer. In addition, elevated bladder cancer risk associated with high read meat intake was most significant among individuals with a high number of unfavorable genotypes in the heterocyclic amine (HCA) metabolic pathways.

"These results strongly support that red meat intake and genetic variants in the HCA metabolic pathways jointly influence bladder cancer susceptibility," Lin and colleagues conclude.

Abstract No. 4699
Abstract No. 2825
More Information

Specialties Hematology & Oncology
Pathology
Pharmacy
Pulmonology
Diabetes & Endocrinology
Internal Medicine
Family Practice
Geriatrics

Copyright © 2010 HealthDay. All rights reserved.


I Wish You Knew

What is Photodynamic Therapy and how is it used in cancer care?

View More



Blogs and Web Chats

OncoLink Blogs give our readers a chance to react to and comment on key cancer news topics and provides a forum for OncoLink Experts and readers to share opinions and learn from each other.




OncoLink OncoPilot

Facing a new cancer diagnosis or changing the course of your current treatment? Let our cancer nurses help you through!

Learn More