Female survivors have higher risk of complications with higher doses of flank radiation

-- Lindsey Marcellin

Tuesday, May 11, 2010 (Last Updated: 05/12/2010)

TUESDAY, May 11 (HealthDay News) -- Women who have had prior radiation treatment for unilateral Wilms tumor diagnosed in childhood have a higher risk of pregnancy and birth complications, according to research published online May 10 in the Journal of Clinical Oncology.

Daniel M. Green, M.D., of the St. Jude Children's Research Hospital in Memphis, Tenn., and colleagues reviewed pregnancy outcomes of female Wilms tumor survivors and female partners of male Wilms tumor survivors using a maternal questionnaire and maternal and offspring medical records. A total of 700 sets of maternal/offspring records were reviewed.

The researchers found that an increasing radiation dose in female patients was associated with increased risk for several complications, including hypertension complicating pregnancy, early or threatened labor, and malposition of the fetus. Risk of having a low-birth-weight infant also increased with increased radiation dose, as did risk of premature birth. There was no significant association of congenital fetal anomalies with radiation dose in the mother. In female partners of male Wilms tumor patients, no significant trend was found in the risk for any complication with the radiation dose the father received.

"This study was undertaken to more thoroughly evaluate the effect of various doses of flank radiation therapy on the risk of pregnancy complications, premature birth, and congenital malformations in the offspring of women and the partners of men treated for Wilms tumor during childhood," the authors write. "The obstetrical management of the pregnancies of these women should take these elevated risks into consideration."

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Specialties OBGYN & Women's Health
Hematology & Oncology
Family Practice

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