Cancer News
OncoLink Cancer News - HealthDay


Goserelin Treatment Shows Similar Benefits As Tamoxifen

-- Eric Metcalf

Friday, February 27, 2009

FRIDAY, Feb. 27 (HealthDay News) -- The use of goserelin was associated with improved rates of survival and recurrence over the long term in women with breast cancer, according to research published online Feb. 24 in the Journal of the National Cancer Institute.

Allan Hackshaw, of University College London in the United Kingdom, and colleagues analyzed data from 2,706 premenopausal women with breast cancer treated with primary therapy who were randomized to receive either goserelin or tamoxifen, or both treatments for two years, or no endocrine therapy.

In those not taking tamoxifen, goserelin was linked to a 33 percent decrease in risk of an event-free survival event (recurrence, new tumor or death), a 34 percent decrease in risk of recurrence, and a 29 percent decrease in risk of breast cancer mortality, the investigators found. A smaller benefit from the drug was seen in women also taking tamoxifen, the researchers report.

"In summary, long-term follow-up of our large trial showed that goserelin had a demonstrable effect on survival and recurrence 15 years after starting treatment and is as effective as tamoxifen when each are given for two years," the authors conclude. "It may be that women who are unlikely to complete five years of tamoxifen tablets may prefer two years of goserelin injections. It may also be reasonable to recommend both therapies to minimize the reduction in bone mineral density associated with endocrine treatment."

AstraZeneca (the maker of goserelin), Cancer Research UK, and the King Gustaf V Jubilee Fund supported the study. A co-author disclosed other relationships with AstraZeneca.

Abstract
Full Text

Specialties Cardiology
Diabetes & Endocrinology
Internal Medicine
Family Practice

Copyright © 2009 ScoutNews, LLC. All rights reserved.


I Wish You Knew

OncoLink/LIVESTRONG Care Plan

View More



Blogs and Web Chats

OncoLink Blogs give our readers a chance to react to and comment on key cancer news topics and provides a forum for OncoLink Experts and readers to share opinions and learn from each other.




OncoLink OncoPilot

Facing a new cancer diagnosis or changing the course of your current treatment? Let our cancer nurses help you through!

Learn More