Younger age, red hair, higher socioeconomic status linked to increased risk of multiple lesions

-- Beth Gilbert

Wednesday, August 18, 2010 (Last Updated: 08/19/2010)

WEDNESDAY, Aug. 18 (HealthDay News) -- Individuals who have red hair, are of higher socioeconomic status, are relatively young upon initial basal cell carcinoma (BCC) diagnosis, and/or develop a BCC lesion on their upper extremities have an increased risk of developing multiple BCC lesions, according to a study in the August issue of the Archives of Dermatology.

In a prospective, population-based cohort study, Ville Kiiski, M.D., of the Erasmus Medical Center in Rotterdam, Netherlands, and colleagues identified individuals with BCC lesions from the Dutch national pathology laboratories network, hospitals, and general practices to assess the incidence of single and multiple BCC lesions and associated risk factors.

Among 10,820 eligible cohort members, the investigators found that 4.8 percent had BCC, and 31.1 percent of them had multiple lesions. In a multivariate model, significant risk factors for a first BCC lesion included age and red hair. While individuals who developed a first BCC lesion after 75 years of age were significantly less likely to develop multiple lesions, individuals with red hair, high educational level, and/or a first BCC lesion located on the upper extremities were at a significantly increased risk of developing multiple lesions.

"More research is needed to identify people who are at risk of developing multiple lesions because the follow-up of this large group of people is putting a strain on limited specialized care," the authors write.

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Specialties Dermatology

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