Study looks at Charlson Comorbidity Index score in men undergoing radical prostatectomy

-- Eric Metcalf

Thursday, September 30, 2010 (Last Updated: 10/01/2010)

THURSDAY, Sept. 30 (HealthDay News) -- Men undergoing radical prostatectomy who have greater comorbidity after surgery also have a higher risk of death from other causes than prostate cancer, so assessing patients' other conditions may be advisable when considering treatment, according to research published in the September issue of Urology.

Thomas J. Guzzo, M.D., of the Hospital of the University of Pennsylvania in Philadelphia, and colleagues analyzed data from 14,052 men who underwent radical prostatectomy between 1983 and 2006. They calculated the subjects' Charlson Comorbidity Index (CCI) score using hospital discharge records.

The researchers found that, over a median of 7.6 years of follow-up, most deaths (70.6 percent) were from causes other than prostate cancer. Men with a CCI of two or higher had a higher risk of death from causes aside from prostate cancer than men with lower CCI scores (hazard ratio, 2.18). The finding appeared stronger in African-American men. The authors write that use of a standardized tool to assess perioperative comorbidities may be warranted to help providers make appropriate recommendations for treatment.

"This is a thoughtful cohort analysis of prostate cancer patients undergoing radical prostatectomy which examined associations of the CCI -- a robust measure of global patient health -- with death from causes other than prostate cancer. These data add to a growing body of evidence demonstrating strong links between validated morbidity indexes and non-cancer death in prostate cancer patients undergoing treatment with intent to cure," writes the author of an accompanying editorial.

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Specialties Hematology & Oncology
OBGYN & Women's Health
Family Practice
Diabetes & Endocrinology

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