Follicle-stimulating hormone receptor expressed by tumor endothelial cells, not nearby normal tissue

-- Eric Metcalf

Wednesday, October 20, 2010 (Last Updated: 10/21/2010)

WEDNESDAY, Oct. 20 (HealthDay News) -- The endothelial cells of blood vessels in a variety of types of tumors express the follicle-stimulating hormone (FSH) receptor, according to research published in the Oct. 21 issue of the New England Journal of Medicine.

Aurelian Radu, Ph.D., of the Mount Sinai School of Medicine in New York City, and colleagues analyzed data from tumor specimens taken from 1,336 patients immediately after surgery.

The researchers found that, in all patients, endothelial cells in tumors of all grades expressed FSH receptor. These included tumors found in the prostate, colon, breast, pancreas, bladder, lung, liver, and other sites. FSH receptor wasn't expressed in normal tissue more than 10 mm from the tumor or in tumor lymphatic vessels. Endothelial cells expressing the receptor were found in a roughly 10-mm thick layer at the periphery of the tumors.

"If it becomes possible to exploit FSH-receptor expression for imaging purposes, the location of the FSH-receptor signal at the boundary between the tumoral and the normal tissues should make it useful for defining the target volume for radiation therapy or surgery," the authors write. "If it can be shown that intravenously administered antibodies can detect tumor endothelial cells, the presence of FSH receptor on the surface of these cells in a wide range of tumors makes it a potential target for both tumor imaging and therapy."

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Specialties Hematology & Oncology

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