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More cancers detected in women with personal breast cancer history versus genetic, family history

Monday, November 29, 2010 (Last Updated: 11/30/2010)

MONDAY, Nov. 29 (HealthDay News) -- Women with a personal history of breast cancer may benefit from annual magnetic resonance imaging (MRI) screening in addition to mammography, according to a study presented at the annual meeting of the Radiological Society of North America, held from Nov. 28 to Dec. 3 in Chicago.

In a retrospective analysis, Wendy B. DeMartini, M.D., of the University of Washington Medical Center in Seattle, and colleagues evaluated initial screening breast MRI examinations of more than 1,000 women between January 2004 and June 2009, including 327 women with a genetic or family history of breast cancer and 646 with a personal history of treated breast cancer.

The investigators found that MRI screening identified 25 of 27 cancers, with a sensitivity rate of 92.6 percent. The cancer yield in the women with a personal history of breast cancer was 3.1 percent, and it was 1.5 percent in women with a genetic or family history of the disease. The specificity in women with a personal history of breast cancer was 93.6 percent, and it was 86.3 percent among those with a genetic or family history of the disease. Biopsy was recommended in 9.3 percent of women with a personal history of breast cancer and 15 percent of those with a genetic or family history of the disease.

"Our findings show that the diagnostic performance of MRI in patients with a personal history of treated breast cancer supports consideration of screening MRI as an adjunct to mammography," DeMartini said in a statement. "Additional studies such as ours are necessary to establish guidelines for screening this important group of women."

Two authors disclosed financial relationships with General Electric Company, Johnson & Johnson, and/or Koninklijke Philips Electronics.

Abstract No. SSA01-01
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Specialties Rheumatology
Family Practice
Internal Medicine
Pathology

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