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Damaged Repair Genes Increase Hodgkin's Disease Risk

-- Jeff Muise

Friday, March 13, 2009

FRIDAY, Mar. 13 (HealthDay News) -- Single-nucleotide polymorphisms (SNP) in DNA repair genes appear to increase the risk of developing Hodgkin's disease, especially when the SNPs occur in more than one of the repair gene types, according to research published in the Apr. 15 issue of Cancer.

Randa El-Zein, M.D., Ph.D., of the University of Texas M.D. Anderson Cancer Center in Houston, and colleagues evaluated polymorphisms and Hodgkin's disease risk in five genes: three nucleotide excision repair pathway genes (XPD, XPC, and XPG), base excision repair gene XRCC1, and double-strand break repair gene XRCC3. The research was carried out with 200 subjects with Hodgkin's disease and 220 subjects without Hodgkin's disease.

The researchers found that patients heterozygous for the XRCC1 Arg/Gln genotype had a 77 percent increase in Hodgkin's disease risk, the highest risk found for an individual SNP. For combinations, XRCC3 (Thr/Met) with XRCC1 (Arg/Gln) nearly doubled Hodgkin's disease risk (odds ratio 1.97); XRCC3 (Thr/Thr) with the XRCC1 (Gln/Gln) tripled risk (odds ratio 3.00); and XRCC3 (Met/Met) with XRCC1 (Arg/Gln) more than quadrupled risk (odds ratio 4.13). XPC Lys/Lys with XRCC1 Arg/Gln more than doubled Hodgkin's disease risk (odds ratio 2.14), the report indicates.

"Given the multiple pathways involved in repairing DNA damage, genetic variants in the different repair pathways should be further evaluated to better understand cancer susceptibility in these patients," the authors write.

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Specialties Cardiology
Diabetes & Endocrinology
Internal Medicine
Family Practice

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