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Women without a strong family history receiving estrogen as HRT have reduced risk

Thursday, December 9, 2010 (Last Updated: 12/10/2010)

THURSDAY, Dec. 9 (HealthDay News) -- Hormone replacement therapy (HRT) involving estrogen alone appears to reduce the risk of breast cancer among women without a strong family history of the disease, according a study presented at the annual San Antonio Breast Cancer Symposium, held from Dec. 8 to 12.

In a retrospective review of data from the Women's Health Initiative (WHI) trials, Joseph Ragaz, M.D., of the University of British Columbia in Vancouver, Canada, and colleagues evaluated women without a uterus who received estrogen alone and women with a uterus who received estrogen plus progestin.

The investigators found that women without a strong family history of breast cancer who received estrogen alone had a significantly reduced incidence of breast cancer. The researchers also found that the 75 percent of women without benign disease before trial enrollment had a reduced risk of breast cancer.

"The recommendations based on prior analyses of the results of the WHI HRT studies were not to use HRT, but we are optimistic this will change," Ragaz said in a statement. "Our conclusion, based on the data presented, should enhance considerations for an early approval of HRT based on estrogen-alone for the majority of selected women suffering with menopausal symptoms and galvanize new research on HRT to define the optimum regimens for individual women."

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Specialties Hematology & Oncology
OBGYN & Women's Health
Internal Medicine

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