Tuesday, December 28, 2010 (Last Updated: 12/29/2010)
TUESDAY, Dec. 28 (HealthDay News) -- Screening for esophageal adenocarcinoma (EAC) is not warranted in younger white men with gastroesophageal reflux disease (GERD) or white women of any age with GERD symptoms, according to research published online Dec. 7 in the American Journal of Gastroenterology.
Joel H. Rubenstein, M.D., of the Veterans Affairs Center of Excellence for Clinical Management Research in Ann Arbor, Mich., and colleagues analyzed data from a Markov computer model to estimate incidences of EAC in non-Hispanic whites with GERD symptoms.
The researchers found that EAC incidence in men under 50 with GERD symptoms was very low. However, the incidence in older men with weekly symptoms was considerable. For example, incidence in 35-year-olds and 70-year-olds was 1.0 and 60.8 per 100,000 person-years, respectively. Incidence in women with GERD was found to be low, along the lines of incidence of breast cancer in men. The authors concluded that there was no need to screen for EAC in women of any age or men younger than 50.
"The incidence of EAC is substantial in white men with at least weekly GERD who are above the age of 60 years, and in white men with at least daily GERD who are at least 55 years of age. Screening for EAC in these groups of men might be reasonable if the practice were effective; however, there is no high-quality evidence to support the contention that screening is effective for reducing mortality from EAC," the authors write.
Two co-authors disclosed financial relationships with several pharmaceutical and other companies.
Hematology & Oncology
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