Older patients have greater risk for biochemical recurrence of prostate cancer
Monday, January 31, 2011 (Last Updated: 02/01/2011)
MONDAY, Jan. 31 (HealthDay News) -- As men age, parameters that are consistent with more aggressive prostate cancer become prevalent, according to research published in the January issue of The Journal of Urology.
Stephen A. Brassell, M.D., of the Walter Reed Army Medical Center in Washington, D.C., and colleagues analyzed data from 12,081 men in the Center for Prostate Disease Research database. Patient clinicopathological features and outcomes were analyzed.
The researchers found that men 70 years or older (30.2 percent) had a higher clinical stage, biopsy grade, and prediagnosis prostate-specific antigen velocity. For patients of this age group who underwent prostatectomy, pathological stage, grade, and surgical margin status were all significantly increased compared with younger men. Men aged 70 or older had a 1.45-fold greater hazard risk of biochemical recurrence following prostatectomy. Overall survival was lowest for men of this age group who underwent surgery.
"Clinicopathological features of prostate cancer appear to be more aggressive as one ages. We found that men 70 years old or older had worse outcomes with respect to biochemical recurrence-free, prostate cancer specific and overall survival. Implications for screening and treatment recommendations are yet to be defined," the authors write.
One of the study authors disclosed financial relationships with GlaxoSmithKline and AstraZeneca.
Hematology & Oncology
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