Men with diabetes aged 40 to 64 years have most elevated risk of prostate cancer

Monday, March 21, 2011 (Last Updated: 03/22/2011)

MONDAY, March 21 (HealthDay News) -- The incidence of prostate cancer among men in Taiwan is increasing, and men with diabetes are at an increased risk of prostate cancer, according to research published in the March issue of Diabetes Care.

Chin-Hsiao Tseng, M.D., Ph.D., of the National Taiwan University College of Medicine in Taipei, investigated the incidence of age-standardized prostate cancer in the Taiwanese general population, and its link to diabetes. Using data from a random sample of one million individuals from the National Health Insurance database, the trend of prostate cancer incidence was calculated between 1995 and 2006. A sample of 494,630 men without prostate cancer was followed from 2003 to the end of 2005. Cumulative incidence and risk ratios for prostate cancer were calculated.

The researchers found a significant increase in the trend of prostate cancer incidence, and that men with diabetes were at a higher risk of developing prostate cancer compared to men without diabetes. The youngest group of men, aged 40 to 64 years, had the highest risk ratio (RR, 2.09), compared to all ages. Men aged 65 to 74 years (RR, 1.35) and those aged 75 and older (RR, 1.39) also had an increased risk. Elevated risk of prostate cancer was significantly correlated with age, diabetes, nephropathy, ischemic heart disease, dyslipidemia, living region, and occupation, but not with medications, including insulin and oral antidiabetic agents.

"Prostate cancer incidence is increasing in Taiwan. A positive link between diabetes and prostate cancer is observed, which is more remarkable in the youngest age of 40 to 64 years," the author writes.

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Specialties Pediatrics
Family Practice
Diabetes & Endocrinology
Hematology & Oncology

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