Tumors have more aggressive histology and require more stages of excision than primary BCC
Monday, April 18, 2011 (Last Updated: 04/19/2011)
MONDAY, April 18 (HealthDay News) -- Patients with basal cell carcinoma (BCC) developing post-laser ablations have a longer disease interval to diagnosis and a more aggressive disease pattern compared to those with primary BCC, according to a study published in the April issue of the Journal of the American Academy of Dermatology.
Do-Sang Jung, M.D., from Pusan National University in Korea, and colleagues compared the clinical and surgical features of BCC developing from undiagnosed lesions following laser ablation with those of primary BCC. A total of 359 patients with 373 biopsy-verified BCC lesions were treated with Mohs micrographic surgery (MMS) from 1998 to 2008. BCC was categorized as primary or post-laser (58 lesions), and features were assessed using clinical photographs, histological data, and MMS results.
The investigators found that patients in the post-laser BCC group had a significantly longer disease interval to pathological diagnosis than the primary BCC group. In histological analysis, the micronodular pattern was found more frequently in the post-laser group compared with the primary BCC group. In the post-laser group, significantly fewer tumors were eradicated by one Mohs stage excision, and more required two or more stages of excision compared with the primary BCC group.
"This study showed that post-laser BCC may be associated with a higher risk for invasion and more aggressive behavior. The findings of this study underscore the importance of differentiating malignant lesions from nonmalignant lesions by the treating physician," the authors write.
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