Approach highly accurate in distinguishing between the two cancer types
Wednesday, May 4, 2011 (Last Updated: 05/05/2011)
WEDNESDAY, May 4 (HealthDay News) -- Magnetic resonance imaging (MRI) appears to be effective at distinguishing between endometrial and cervical cancer even when biopsy results are inconclusive, according to research presented at the annual meeting of the American Roentgen Ray Society, held from May 1 to 6 in Chicago.
Heather He, M.D., Ph.D., of the MD Anderson Cancer Center in Houston, and colleagues reviewed an institutional database for all patients in the past 13 years who had a total hysterectomy for suspected unknown primary tumor of the uterus (endometrial versus cervical). Pelvic MR images were available in 48 patients, and these were reviewed separately by two body radiologists specializing in gynecological oncologic imaging. The radiologists were blinded to any clinical and pathological information, and if there was discordance between them, they reached consensus at a separate session.
Using MRI, the radiologists correctly identified the primary site of cancer in 79 percent of cases (38 of 48 patients) when biopsy results were inconclusive. The sensitivity to detect endometrial adenocarcinoma by MRI was 87 percent, while the specificity, positive predictive value, negative predictive value, and accuracy were 89, 97, 62, and 88 percent, respectively. In addition, the sensitivity to detect cervical adenocarcinoma by MRI was 80 percent, while the specificity, positive predictive value, negative predictive value, and accuracy were 88, 44, 97, and 88 percent, respectively.
"In about 3 percent of the cases, there is difficulty determining the primary cancer site," He said in a statement. "Knowing the primary cancer site means that we can give the patients the most appropriate therapy and save some patients from unnecessary surgery."
Hematology & Oncology
OBGYN & Women's Health
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