Wednesday, June 8, 2011 (Last Updated: 06/09/2011)
WEDNESDAY, June 8 (HealthDay News) -- Parkinson's disease (PD) is associated with a moderately higher occurrence of melanoma, according to a review published in the June 7 issue of Neurology.
Rui Liu, Ph.D., from the National Institute of Environmental Health Sciences in Research Triangle Park, N.C., and colleagues reviewed available literature from 1965 to 2010 to provide a quantitative assessment of current epidemiologic evidence on melanoma in relation to PD. Pooled odds ratios (ORs) were evaluated from 12 studies included in the analysis.
The investigators found that PD was associated with an increased risk of melanoma occurrence with pooled ORs of 2.11 overall, 2.04 for men, and 1.52 for women. A temporal relationship analysis showed a significantly higher occurrence of melanoma after the diagnosis of PD (OR, 3.61) than before its diagnosis (OR, 1.07; 95 percent confidence interval, 0.62 to 1.84). The occurrence before diagnosis was found to be significant after exclusion of one study from the analysis (OR, 1.44; 95 percent confidence interval, 1.06 to 1.96). Nonmelanoma skin cancers were not found to be significantly associated with PD.
"We confirmed an association between PD and a higher occurrence of melanoma. The association was similar in both men and women and appears to be bidirectional. We did not find a significant association between nonmelanoma skin cancers and PD," the authors write.
Hematology & Oncology
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