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Radical pleurectomy, photodynamic therapy improve malignant pleural mesothelioma outcome

Monday, June 13, 2011 (Last Updated: 06/14/2011)

MONDAY, June 13 (HealthDay News) -- Patients with malignant pleural mesothelioma who are treated with radical pleurectomy (RP) and intraoperative photodynamic therapy (PDT) have improved overall survival compared to those treated with modified extrapleural pneumonectomy (MEPP), according to a study published in the June issue of The Annals of Thoracic Surgery.

Joseph S. Friedberg, M.D., from the University of Pennsylvania in Philadelphia, and colleagues compared the treatment outcomes for 28 patients with malignant pleural mesothelioma treated with MEPP (14 cases) or RP and PDT (14 cases). Patients underwent macroscopic complete resection from 2004 to 2008. Due to the evolution of surgical techniques, 13 of the last 16 patients underwent lung-sparing procedures, even for large-bulk tumors.

The investigators found that stage III/IV disease was present in 12 of 14 patients in both groups, and 50 percent or more patients had +N2 disease. The median overall survival was 8.4 months in patients treated with MEPP. For patients treated with RP and PDT, median overall survival had not yet been reached, after an average follow-up of 2.1 years.

"We believe RP plus PDT is a reasonable option for appropriate patients pursuing a surgical treatment for malignant pleural mesothelioma and that this procedure can serve as the backbone of surgically based multimodal treatments," the authors write.

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Specialties Hematology & Oncology
Pharmacy
Surgery
Pulmonology

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