Friday, September 23, 2011 (Last Updated: 09/26/2011)
FRIDAY, Sept. 23 (HealthDay News) -- The levels of certain serum amino acids are significantly different in patients with renal cell carcinoma and show potential as biomarkers with predictive value for tumor recurrence and overall survival, according to a study published in the October issue of The Journal of Urology.
Aladdin Mustafa, M.D., from the Fox Chase Cancer Center in Philadelphia, and colleagues investigated the usefulness of serum amino acid profiles as biomarkers in patients with renal cell carcinoma. Serum was collected preoperatively from 189 patients with renal cell carcinoma and 104 age- and sex-matched controls, and assessed for concentration of 26 amino acids.
The investigators found significant changes in 15 amino acids levels: 13 amino acids decreased and two increased. A receiver-operator curve based on an eight-amino-acid model had an area under the curve of 0.81, and was predictive of overall survival and tumor recurrence in patients with renal cell carcinoma.
"We have shown for the first time that alterations in serum amino acid profiles are characteristic of individuals with early- and late-stage renal cell cancer; in addition, serum amino acid profiles had predictive value regarding overall survival and tumor recurrence in patients with renal cell cancer," the authors write.
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