Thursday, January 19, 2012 (Last Updated: 01/20/2012)THURSDAY, Jan. 19 (HealthDay News) -- Use of backscattering intensity measurements in optical coherence tomography (OCT) for the diagnosis of cervical intraepithelial neoplasia (CIN) is influenced by perceptual and or cognitive bias, according to a study published in the January issue of Lasers in Surgery and Medicine.
Julia Gallwas, M.D., of Ludwig-Maximilians University in Munich, Germany, and colleagues evaluated the value of backscattering intensity measurements in OCT for identifying different grades of cervical intraepithelial dysplasia. Images from 153 areas of 30 conisation and hysterectomy specimens were evaluated by investigators and compared to histology. Linear Discriminant Analysis (LDA) was used to explore the extent to which backscattering intensity profiles of OCT images were able to provide a reliable and valid diagnosis.
The researchers found that, based on histology and OCT, the diagnostic process seemed to involve two variables: the first reflecting the definiteness with which CIN classes are identified and the second representing a bias toward diagnosing inflammation in OCT-based judgments. In the LDA, there was a difference seen in histology and OCT with respect to the positions of inflammation and CIN1.
"The systematic differences between histology-based and OCT-based diagnoses suggest that the use of available information is influenced by perceptual and/or cognitive biases. Apart from this, it seems that the profiles appear to provide a remarkably large amount of information determining the main course of the diagnostic process," the authors write.
One of the study authors disclosed financial ties to Imalux Corporation.
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