Cancer News
OncoLink Cancer News - HealthDay

Breast Cancer Prevention Drug Linked to Bone Loss

Tuesday, February 7, 2012 (Last Updated: 02/08/2012)

TUESDAY, Feb. 7 (HealthDay News) -- Postmenopausal women receiving the aromatase inhibitor exemestane to prevent breast cancer are more likely to have bone loss, according to a study published online Feb. 7 in The Lancet Oncology.

Angela M. Cheung, M.D., from the University Health Network in Toronto, and colleagues analyzed bone mineral density (BMD) data from 351 postmenopausal women (median age, 61.3 years) who had been randomized to receive placebo or exemestane as part of a breast cancer prevention clinical trial.

After two years, the researchers found that, at the distal radius, total volumetric BMD and cortical thickness fell significantly more in women receiving exemestane compared with placebo (mean loss, 6.1 versus 1.8 percent and 7.9 versus 1.1 percent, respectively). Similar results were observed at the distal tibia (mean loss, 5.0 versus 1.3 percent and 7.6 versus 0.7 percent, respectively). Areal BMD also fell significantly more in the exemestane group at the lumbar spine, total hip, and femoral neck.

"Two years of treatment with exemestane worsens age-related bone loss in postmenopausal women despite calcium and vitamin D supplementation," Cheung and colleagues conclude. "To assess the effect of our findings on fracture risk, long-term follow-up is needed."

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Specialties Hematology & Oncology
Internal Medicine
Family Practice

Copyright © 2012 HealthDay. All rights reserved.

I Wish You Knew

Pain management in cancer care - are patients getting what they need?

View More

Blogs and Web Chats

OncoLink Blogs give our readers a chance to react to and comment on key cancer news topics and provides a forum for OncoLink Experts and readers to share opinions and learn from each other.

OncoLink OncoPilot

Facing a new cancer diagnosis or changing the course of your current treatment? Let our cancer nurses help you through!

Learn More