Cancer News
OncoLink Cancer News - HealthDay


Colonoscopic Removal of Adenomas Cuts CRC Mortality

Wednesday, February 22, 2012 (Last Updated: 02/23/2012)

WEDNESDAY, Feb. 22 (HealthDay News) -- Colonoscopic removal of adenomatous polyps reduces colorectal cancer mortality, and interim analysis shows that fecal immunochemical testing (FIT) yields similar results to colonoscopy; however, more polyps are identified with colonoscopy screening compared to FIT, according to two studies published in the Feb. 23 issue of the New England Journal of Medicine.

Ann G. Zauber, Ph.D., from the Memorial Sloan-Kettering Cancer Center in New York City, and colleagues investigated the long-term effect of colonoscopic polypectomy in 2,602 patients who had adenomas removed between 1980 and 1990. Patients were followed for a median of 15.8 years, during which time, 1,246 patients died from any causes and 12 died from colorectal cancer. The standardized incidence-based mortality ratio was 0.47 with colonoscopic polypectomy, based on an estimated 25.4 expected deaths from colorectal cancer in the general population.

Enrique Quintero, M.D., Ph.D., from the Hospital Universitario de Canarias in Tenerife, Spain, and colleagues conducted a randomized trial in asymptomatic adults aged 50 to 69 years, comparing one-time colonoscopy in 26,703 adults with FIT every two years in 26,599 adults. The researchers found that, compared with the colonoscopy group, the rate of participation in the FIT group was significantly higher (34.2 versus 24.6 percent; P < 0.001). Colorectal cancer was found in 0.1 percent of both groups. Advanced adenomas were detected in 1.9 and 0.9 percent of the colonoscopy and FIT groups, respectively (odds ratio, 2.30; 95 percent confidence interval [CI], 1.97 to 2.69; P < 0.001), and nonadvanced adenomas were detected in 4.2 and 0.4 percent, respectively (odds ratio, 9.80; 95 percent CI, 8.10 to 11.85; P < 0.001).

"The numbers of subjects in whom colorectal cancer was detected were similar in the two study groups, but more adenomas were identified in the colonoscopy group," Quintero and colleagues write.

Eiken Chemical of Japan, Palex Medical, and Biogen Diagnóstica donated supplies and automated analyzers used for FIT in the Quintero study.

Full Text - Zauber (subscription or payment may be required)
Full Text - Quintero (subscription or payment may be required)
Editorial (subscription or payment may be required)

Specialties Hematology & Oncology
OBGYN & Women's Health
Nursing
Family Practice
Pathology

Copyright © 2012 HealthDay. All rights reserved.


I Wish You Knew

Screening with Mammography: Looking at the Controversy

View More



Blogs and Web Chats

OncoLink Blogs give our readers a chance to react to and comment on key cancer news topics and provides a forum for OncoLink Experts and readers to share opinions and learn from each other.




OncoLink OncoPilot

Facing a new cancer diagnosis or changing the course of your current treatment? Let our cancer nurses help you through!

Learn More