Survival Poor in Adults with Rhabdomyosarcoma-- A. Agrawal, PhD
Tuesday, April 28, 2009
TUESDAY, April 28 (HealthDay News) -- Adults with rhabdomyosarcoma, though rare, have significantly worse long-term survival than children with the disease, although many of the same factors predict survival in both cases, according to a study published online April 27 in the Journal of Clinical Oncology.
Iyad Sultan, M.D., from the King Hussein Cancer Center in Amman, Jordan, and colleagues analyzed mortality data from 1,071 adults and 1,529 children living in the United States who were diagnosed with rhabdomyosarcoma between 1973 and 2005.
The researchers found that adults with rhabdomyosarcoma had significantly worse five-year survival (27 versus 61 percent) and had tumors that were more likely to be at an unfavorable site (65 versus 55 percent) or to have histologies not commonly found in children. Adults also had significantly worse outcomes than children with similar tumors, with the most significant difference being a lower five-year survival for localized disease (47 versus 82 percent). Independent predictors of survival included age, histologic subtype (with the exception of alveolar for adults), primary site location (children only), stage, and local control with surgery and radiation.
"Adults reported to have rhabdomyosarcoma had worse survival than children with similar tumors," Sultan and colleagues conclude. "Predictors of poor outcome in children were valid in adults except for alveolar histology and unfavorable tumor site."
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