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March 2012 Briefing - Hematology & Oncology

Monday, April 2, 2012 (Last Updated: 04/03/2012)

Here are what the editors at HealthDay consider to be the most important developments in Hematology & Oncology for March 2012. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Liver Cancer Patients Less Likely to Die on Transplant List

FRIDAY, March 30 (HealthDay News) -- Liver transplantation candidates with hepatocellular carcinoma (HCC) have significantly lower 90-day odds of waitlist removal due to clinical deterioration or death compared to non-HCC candidates with similar Model for End-Stage Liver Disease (MELD) scores, according to a study published in the April issue of Liver Transplantation.

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Nanobodies Noninvasively Detect Atherosclerosis in Mice

FRIDAY, March 30 (HealthDay News) -- A radiolabeled antibody fragment targeting vascular cell adhesion molecule-1 (VCAM1) can noninvasively and specifically detect atherosclerotic plaques in mice, according to an experimental study published in the March 30 issue of Circulation Research.

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Adherence to Cancer Surveillance Guidelines Varies

FRIDAY, March 30 (HealthDay News) -- Insured breast cancer survivors have high rates of guideline-recommended recurrence testing and non-recommended metastatic testing, while only about half of colorectal cancer survivors undergo recommended surveillance and two-thirds receive non-recommended metastatic testing, according to a study published online March 20 in Cancer.

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Better Short-Term Outcomes for Private Prostatectomies

FRIDAY, March 30 (HealthDay News) -- For men undergoing radical prostatectomies (RPs), private health insurance coverage is linked with fewer complications, less in-hospital recovery time, and decreased mortality, compared to public coverage, according to a study published in the April 1 issue of Cancer.

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Stigma Affects Depression Among Lung Cancer Patients

THURSDAY, March 29 (HealthDay News) -- For patients with lung cancer, perceived stigma is significantly associated with depressive symptomatology, according to a study published in the March issue of Psycho-Oncology.

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Polymorphism in Opioid Gene Affects Breast Cancer Survival

THURSDAY, March 29 (HealthDay News) -- Genotype at the A118G polymorphism of the µ-opioid receptor gene is associated with breast cancer-specific mortality, according to a study published in the April issue of Anesthesiology.

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Point-of-Care Genetic Testing Feasible After PCI

THURSDAY, March 29 (HealthDay News) -- For patients who undergo percutaneous coronary intervention (PCI), point-of-care genetic testing is feasible and identifies carriers of a CYP2C19*2 allele with high sensitivity and specificity, according to a proof-of-concept study published online March 29 in The Lancet.

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Chemo-Linked Factors May Impact Weight in Breast Cancer

THURSDAY, March 29 (HealthDay News) -- Adjuvant chemotherapy for early-stage breast cancer can induce weight gain and a variety of metabolic changes that may be associated with a poor prognosis for some patients, according to research published in the April issue of Obesity Reviews.

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Study Finds Psoriasis Treatment Increases Skin Cancer Risk

THURSDAY, March 29 (HealthDay News) -- The long-term risk of squamous cell carcinoma (SCC) is significantly increased for patients with severe psoriasis who receive more than 350 psoralen and ultraviolet A (PUVA) treatments compared with those who receive fewer than 50 treatments, according to research published in the April issue of the Journal of the American Academy of Dermatology.

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Prophylaxis With Apixaban Feasible for Cancer Patients

THURSDAY, March 29 (HealthDay News) -- Primary venous thromboembolism prophylaxis with apixaban, an oral direct Factor Xa inhibitor, in ambulatory cancer patients undergoing first- or second-line chemotherapy for advanced or metastatic cancer, is safe and well tolerated, according to a phase II study published online March 12 in the Journal of Thrombosis and Haemostasis.

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Conditioning Regimen Beneficial for Kidney Recipients

WEDNESDAY, March 28 (HealthDay News) -- Following a conditioning regimen of lymphoid irradiation (TLI) and antithymocyte globulin (ATG), the majority of HLA-matched kidney and hematopoietic cell transplant recipients can be withdrawn from immunosuppressive drugs, according to a small study published online March 8 in the American Journal of Transplantation.

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Vaccine Cuts Risk of Subsequent HPV-Related Disease

WEDNESDAY, March 28 (HealthDay News) -- Women surgically treated for human papillomavirus (HPV)-related disease who were previously vaccinated with the quadrivalent HPV vaccine have reduced incidence of subsequent HPV-related disease, according to a study published online March 27 in BMJ.

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National Survey Describes Cancer-Related Deaths in India

WEDNESDAY, March 28 (HealthDay News) -- Most cancer-related deaths in India occur in those aged 30 to 69 years, with tobacco-related cancers accounting for a considerable proportion of cancer-related deaths, according to a study published online March 28 in The Lancet.

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Longer Course of Imatinib Better in Trial for GI Stromal Tumor

TUESDAY, March 27 (HealthDay News) -- A longer course of imatinib (36 months versus 12 months) significantly improves recurrence-free survival (RFS) and overall survival in postoperative patients at high risk for recurrence of gastrointestinal stromal tumor (GIST), according to a study published in the March 28 issue of the Journal of the American Medical Association.

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Omontys Approved for Anemia in Kidney Disease Patients

TUESDAY, March 27 (HealthDay News) -- Omontys (peginesatide) has been approved by the U.S. Food and Drug Administration to treat anemia in adults who require dialysis due to chronic kidney disease.

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Quality of Life Linked to Overall Survival in NSCLC

TUESDAY, March 27 (HealthDay News) -- For patients with non-small-cell lung cancer (NSCLC), quality of life (QOL) assessments at the time of diagnosis are associated with overall survival (OS); and genetic variations are linked to QOL measures, according to two studies published online March 26 in the Journal of Clinical Oncology.

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Insulin Resistance Increases Risk of Colorectal Adenomas

TUESDAY, March 27 (HealthDay News) -- Insulin resistance (IR) and central obesity, as measured by waist to hip ratio (WHR), are associated with a significantly increased risk of colorectal adenomas, especially in men, according to a study published in the April 1 issue of Cancer.

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Ipilimumab Active in Advanced Melanoma With Brain Mets

TUESDAY, March 27 (HealthDay News) -- For some patients with advanced melanoma and brain metastases, ipilimumab is active, according to the results of a phase 2 study published online March 27 in The Lancet Oncology.

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New Guidelines Issued for Red Blood Cell Transfusions

MONDAY, March 26 (HealthDay News) -- A restrictive red blood cell transfusion strategy should be employed for hemodynamically stable adults and children, according to a clinical practice guideline issued by the AABB (formerly the American Association of Blood Banks) and published online March 26 in the Annals of Internal Medicine.

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Bevacizumab Doesn't Up Overall Survival in Prostate Cancer

MONDAY, March 26 (HealthDay News) -- For men with metastatic castration-resistant prostate cancer (mCRPC), the addition of bevacizumab (B) to docetaxel plus prednisone (DP) is not associated with improved overall survival (OS), but does improve progression-free survival (PFS) and objective response (OR), according to a study published online March 26 in the Journal of Clinical Oncology.

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Cervical Cancer Mortality Similar in U.S. and Netherlands

MONDAY, March 26 (HealthDay News) -- The cervical cancer screening program used by the Netherlands is as effective as the screening protocol used in the United States, producing similar cervical cancer mortality rates in spite of less screening, according to research published in the March issue of the Milbank Quarterly.

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Plerixafor Active in Refractory Acute Myeloid Leukemia

MONDAY, March 26 (HealthDay News) -- The addition of plerixafor to standard chemotherapy is feasible in acute myeloid leukemia (AML), resulting in reasonable rates of remission, according to the results of a phase I/II study published online Feb. 2 in Blood.

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Few Young Women With Cancer Pursue Fertility Preservation

MONDAY, March 26 (HealthDay News) -- Few women with cancer diagnosed before age 40 take steps to preserve their fertility during treatment, according to a study published online March 26 in Cancer.

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Anal HPV, Cancer Common in Men Having Sex With Men

FRIDAY, March 23 (HealthDay News) -- Men who have sex with men (MSM) are at increased risk for anal human papillomavirus (HPV) infection and anal intraepithelial neoplasia (AIN), according to a meta-analysis published online March 23 in The Lancet Oncology.

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Iron Overload Does Not Worsen Stem Cell Transplant Outcomes

FRIDAY, March 23 (HealthDay News) -- Although iron overload before hematopoietic stem cell transplantation (HSCT) is common, iron does not accumulate after transplantation and is not associated with adverse outcomes in patients with leukemia or myelodysplastic syndrome, according to a study published online March 12 in the American Journal of Hematology.

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DNA Damage Predicts Drug Sensitivity in Breast Cancer

THURSDAY, March 22 (HealthDay News) -- Accumulation of telomeric allelic imbalance is indicative of defective DNA repair and predicts sensitivity to cisplatin treatment in some patients with breast and ovarian cancers, according to a study published online March 22 in Cancer Discovery.

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Glycolytic Enzyme Plays Role in Prostate Cancer Survival

THURSDAY, March 22 (HealthDay News) -- An enzyme that balances the use of glucose for energy generation with the synthesis of antioxidants is important for the growth and survival of prostate cancer, according to a study published online March 22 in Cancer Discovery.

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Health Care Team Members Key for Antimicrobial Stewardship

THURSDAY, March 22 (HealthDay News) -- Antimicrobial stewardship programs (ASPs) that use health care epidemiologists (HEs) and infection preventionists (IPs) have a crucial role to play in the effort to combat health care-associated infections (HAIs), including those caused by multidrug-resistant organisms (MDROs), according to the Association for Professionals in Infection Control and Epidemiology and the Society for Healthcare Epidemiology of America position paper published in the March issue of the American Journal of Infection Control.

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Regular Aspirin Use Can Lower Cancer Risk, Studies Confirm

WEDNESDAY, March 21 (HealthDay News) -- Regular aspirin use is associated with a lower long-term risk of colorectal and other, particularly gastrointestinal, cancers as well as a reduced risk of distant metastasis, according to research published online March 21 in The Lancet Oncology.

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Stem Cells Improve Kidney Transplant Outcomes

WEDNESDAY, March 21 (HealthDay News) -- Patients with end-stage renal disease receiving living-related kidney transplants with autologous mesenchymal stem cells (MSCs) instead of antibody induction therapy have improved outcomes, according to a study published in the March 21 issue of the Journal of the American Medical Association.

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Weight Gain Linked to Hot Flashes After Breast Cancer

WEDNESDAY, March 21 (HealthDay News) -- Early-stage breast cancer survivors who gain at least 10 percent of their pre-diagnosis weight are significantly more likely to report hot flashes than those who remain weight stable, according to a study published online March 19 in the Journal of Clinical Oncology.

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Survey Describes Docs' Online Professionalism Violations

TUESDAY, March 20 (HealthDay News) -- Most medical licensing authorities receive and act upon reports of physicians' online professionalism violations, according to a research letter published in the March 21 issue of the Journal of the American Medical Association.

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'Mindfulness' Stress Reduction Helps Breast Cancer Survivors

TUESDAY, March 20 (HealthDay News) -- A mindfulness-based stress reduction (MBSR) program provides significant and lasting improvements in mood, breast- and endocrine-related quality of life, and well-being, according to research published online March 19 in the Journal of Clinical Oncology.

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Antimicrobial Stewardship Saves Millions of Dollars

TUESDAY, March 20 (HealthDay News) -- Antimicrobial stewardship programs save hospitals millions of dollars, according to a study published in the April issue of Infection Control and Hospital Epidemiology.

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Bevacizumab Active in HIV-Linked Kaposi's Sarcoma

MONDAY, March 19 (HealthDay News) -- For patients with HIV-associated Kaposi's sarcoma (HIV-KS), bevacizumab is tolerated and induces a response in some patients, according to a study published online March 19 in the Journal of Clinical Oncology.

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Most California Hospitals Implementing Infection Control

FRIDAY, March 16 (HealthDay News) -- Most California hospitals implement some policies to improve infection control for multidrug-resistant organisms (MDRO), primarily methicillin-resistant Staphylococcus aureus (MRSA), but few policies are associated with lower MDRO rates, according to a study published in the March issue of the American Journal of Infection Control.

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Poorer Health Literacy Linked to Increased Mortality

FRIDAY, March 16 (HealthDay News) -- A considerable proportion of older adults in England have medium or low health literacy, which is associated with increased mortality, according to a study published online March 15 in BMJ.

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Less Than Half of Potential Lung Cancer Deaths Averted

FRIDAY, March 16 (HealthDay News) -- Despite the positive impact of changes in smoking behavior on the number of lung cancer deaths in the United States, many additional cases could potentially have been averted by complete tobacco control, according to research published online March 14 in the Journal of the National Cancer Institute.

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Dietary Cadmium May Increase Breast Cancer Risk

THURSDAY, March 15 (HealthDay News) -- In postmenopausal women, high dietary cadmium exposure is associated with an increased risk of developing breast cancer, after adjusting for other potential confounders, according to research published in the March 15 issue of Cancer Research.

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Smoking in Movies Increases Smoking Risk for Young Teens

THURSDAY, March 15 (HealthDay News) -- Exposure to smoking in movies in early adolescence is associated with established smoking among adolescents, according to a review published online March 14 in the Journal of the National Cancer Institute.

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Ingenol Mebutate Gel Effective for Actinic Keratoses

THURSDAY, March 15 (HealthDay News) -- Ingenol mebutate gel is an effective treatment for actinic keratoses on the head and body, according to a study published in the March 15 issue of the New England Journal of Medicine.

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Specific Mutations in AML Affect Response to Therapy

WEDNESDAY, March 14 (HealthDay News) -- Patients with acute myeloid leukemia (AML) harboring specific combinations of mutations benefit from high-dose daunorubicin; and the majority of bone marrow cells in myelodysplastic syndromes and secondary AML are clonal and harbor multiple mutations, according to two studies published online March 14 in the New England Journal of Medicine.

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Prostate Cancer Screening Does Not Reduce All-Cause Mortality

WEDNESDAY, March 14 (HealthDay News) -- Screening men for prostate-specific antigen (PSA) levels significantly reduces their risk of death from prostate cancer, but not their overall risk of death, according to a study in the March 15 issue of the New England Journal of Medicine.

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Personal Mobile Computers Improve Resident Efficiency

WEDNESDAY, March 14 (HealthDay News) -- The use of personal mobile computers (Apple iPads) by internal medicine residents improves efficiency, according to a research letter published in the March 12 issue of the Archives of Internal Medicine.

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ATRX Mutation Linked With Age at Diagnosis of Neuroblastoma

TUESDAY, March 13 (HealthDay News) -- Mutations in the ATRX gene are associated with age at diagnosis of advanced-stage neuroblastoma in children and young adults, according to a study published in the March 14 issue of the Journal of the American Medical Association.

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Higher Spending by Hospitals Improves Outcomes

TUESDAY, March 13 (HealthDay News) -- Hospitals that are part of the universal health care system in Canada that spend more on inpatient care have lower rates of deaths and hospital readmissions, according to a study published in the March 14 issue of the Journal of the American Medical Association.

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Higher Red Meat Consumption Linked to Risk of Death

TUESDAY, March 13 (HealthDay News) -- Eating more red meat appears to be associated with an increased risk of all-cause mortality and death from cardiovascular disease (CVD) and cancer specifically, according to research published online March 12 in the Archives of Internal Medicine.

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U.S. Mortality Rates Dropped 60 Percent From 1935 to 2010

TUESDAY, March 13 (HealthDay News) -- From 1935 to 2010, the death rate in the United States decreased considerably, although the single-year improvements in mortality were often small, according to a March data brief issued by the National Center for Health Statistics (NCHS).

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Inflammation, Fatigue Tied to Omega-3 Intake After Breast CA

TUESDAY, March 13 (HealthDay News) -- For breast cancer survivors there may be an association between inflammation, intake of omega-3 polyunsaturated fatty acid (PUFA), and fatigue, with increased intake linked to decreased inflammation and fatigue, according to research published online March 12 in the Journal of Clinical Oncology.

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Financial Hardship Common Among Colon Cancer Patients

TUESDAY, March 13 (HealthDay News) -- Nearly 40 percent of patients undergoing adjuvant chemotherapy for stage III colon cancer experience financial hardship, even if they have health insurance coverage, according to research published online March 12 in the Journal of Clinical Oncology.

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Web-Based Program Helps Manage Cancer-Related Fatigue

TUESDAY, March 13 (HealthDay News) -- An Internet-based educational program helps disease-free cancer survivors better manage their cancer-related fatigue (CRF), according to research published online March 12 in the Journal of Clinical Oncology.

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Asymptomatic Often Sent for Lung Cancer Screening Tests

MONDAY, March 12 (HealthDay News) -- A majority of primary care physicians report ordering lung cancer screening tests for asymptomatic patients, according to research published in the March/April issue of the Annals of Family Medicine.

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Circumcision Reduces Risk of Prostate Cancer

MONDAY, March 12 (HealthDay News) -- Circumcision prior to first sexual intercourse correlates with a reduced risk of prostate cancer (PCa), according to a study published online March 12 in Cancer.

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Flu Vaccine Up Among Medical Staff When They Believe It Works

FRIDAY, March 9 (HealthDay News) -- Hospital health care workers (HCWs) are more likely to receive the seasonal influenza vaccination if they believe it works and are committed to preventing this highly contagious virus, according to research published in the April issue of Occupational & Environmental Medicine.

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Von Willebrand Factor Linked to Bleeding Complications

FRIDAY, March 9 (HealthDay News) -- Oral anticoagulation (OAC)-treated patients with high levels of von Willebrand factor (VWF) have elevated risks of bleeding complications and cardiovascular and all-cause mortality, according to a study published in the March issue of the Journal of Internal Medicine.

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Occult Positive Axillary Nodes in Breast CA Don't Worsen Survival

FRIDAY, March 9 (HealthDay News) -- Occult axillary lymph node metastases do not appear to affect overall or recurrence-free survival in patients with early-stage breast cancer, according to research published in the March 15 issue of Cancer.

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Surrogates Tend to Misinterpret Poor Prognosis Information

FRIDAY, March 9 (HealthDay News) -- Surrogate decision makers for critically ill patients interpret prognostic statements expressing a low risk of death accurately, but interpret statements conveying poor prognosis optimistically, according to a study published in the March 6 issue of the Annals of Internal Medicine.

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Gene-Based Test Identifies Poor-Prognosis Colon Cancers

THURSDAY, March 8 (HealthDay News) -- A sensitive and specific gene-based classifier can be used to identify BRAF mutant colon cancer tumors and a subpopulation of BRAF wild-type tumors with poor prognosis, according to a study published March 5 in the Journal of Clinical Oncology.

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Activities, Smoking Affect Lymph Node Involvement in Melanoma

THURSDAY, March 8 (HealthDay News) -- Several factors, including sporting activity, physical workload, and smoking habits, affect the sonomorphologic characteristics of peripheral lymph nodes (LNs) in patients with a history of invasive cutaneous melanoma, according to research published online Feb. 29 in the Journal of the American Academy of Dermatology.

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Buprenorphine Maintenance Therapy Not Recommended

THURSDAY, March 8 (HealthDay News) -- Opioid substitution therapy with buprenorphine is not recommended for opioid-addicted health care professionals (HCPs), according to research published in the March issue of the Mayo Clinic Proceedings.

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Lung Adenocarcinoma Architecture Predicts Survival

THURSDAY, March 8 (HealthDay News) -- A new method of classifying invasive pulmonary adenocarcinomas, based on the predominant architecture developed by the International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS), is a stage-independent predictor of survival, according to research published online March 5 in the Journal of Clinical Oncology.

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Use of Stem Cells, Conditioning Induces Immune Tolerance

THURSDAY, March 8 (HealthDay News) -- A novel approach using a bioengineered mobilized cellular product enriched with hematopoietic stem cells (HSCs) and tolerogenic graft facilitating cells (FCs) in combination with nonmyeloablative conditioning is safe and practical for inducing immune tolerance after transplantation, according to a study published in the March 7 issue of Science Translational Medicine.

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Intratumor Heterogeneity Seen in Renal Carcinomas

WEDNESDAY, March 7 (HealthDay News) -- Extensive intratumor heterogeneity, seen in samples obtained from renal carcinomas, may lead to underestimation of the tumor genomics based on single tumor-biopsy samples, according to a study published in the March 8 issue of the New England Journal of Medicine.

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Financial Burden of Medical Care Affects One in Three

WEDNESDAY, March 7 (HealthDay News) -- In the first half of 2011, one in three individuals was in a family that experienced the financial burden of medical care in the United States, according to the results of the National Health Interview Survey published March 7 by the National Center for Health Statistics (NCHS).

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Estrogen-Only HRT Lowers Breast CA in Women With Hysterectomy

WEDNESDAY, March 7 (HealthDay News) -- The use of estrogen-only after hysterectomy lowers the risk of breast cancer, but largely in groups already at low risk of breast cancer, according to a study published online March 7 in The Lancet Oncology.

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Long-Term Cardiac Effects for Childhood Cancer Survivors

WEDNESDAY, March 7 (HealthDay News) -- Regardless of exposure to cardiotoxic cancer therapies, survivors of childhood cancers display cardiovascular abnormalities and have markers of increased systemic inflammation and atherosclerotic disease, according to research published online March 5 in the Journal of Clinical Oncology.

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In Suspected PE, A-fib Doesn't Raise Odds of the Diagnosis

WEDNESDAY, March 7 (HealthDay News) -- In general, the presence of atrial fibrillation (AF) does not increase the likelihood of pulmonary embolism (PE), according to a study published in the March issue of the Journal of Thrombosis and Haemostasis.

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Economic Stagnation May Have Increased Mortality Rate

WEDNESDAY, March 7 (HealthDay News) -- From the late 1990s through 2005, mortality rates for Japanese men who worked as professionals or managers began to increase, coinciding with the country's period of economic stagnation, according to research published online March 6 in BMJ.

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Bevacizumab Tied to Improved Telangiectasia Cardiac Output

WEDNESDAY, March 7 (HealthDay News) -- Bevacizumab is associated with improved cardiac output and reduced duration and number of nose bleeds in patients with severe hepatic forms of hereditary hemorrhagic telangiectasia (HHT), according to a phase 2 study published in the March 7 issue of the Journal of the American Medical Association.

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Pten Gene Linked to Longevity and Weight in Mice

TUESDAY, March 6 (HealthDay News) -- Mice carrying extra copies of an anti-cancer gene, Pten, live longer, are protected from cancer, and have hyperactive brown fat, according to an experimental study published in the March 7 issue of Cell Metabolism.

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Regimen Shows Benefit for Advanced Melanoma

TUESDAY, March 6 (HealthDay News) -- A minimal, less-toxic conditioning treatment with cyclophosphamide, that allows cytotoxic T-lymphocyte clones to survive for longer, shows some clinical benefit in patients with refractory, metastatic melanoma, according to a study published online March 5 in the Proceedings of the National Academy of Sciences.

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Electronic Test Result Access Does Not Reduce Test Ordering

TUESDAY, March 6 (HealthDay News) -- For office-based physicians, electronic access to patient imaging and laboratory test results does not decrease -- and may actually increase -- the number of diagnostic tests ordered, according to research published in the March issue of Health Affairs.

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ACP Issues Guidance on Colorectal Cancer Screening

MONDAY, March 5 (HealthDay News) -- Screening of average-risk individuals for colorectal cancer (CRC) should begin at age 50 with a stool-based test, flexible sigmoidoscopy, or colonoscopy, according to a guidance statement from the American College of Physicians (ACP) published in the March 6 issue of the Annals of Internal Medicine.

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Barriers Identified to Pediatric Advance Care Discussions

MONDAY, March 5 (HealthDay News) -- Prognostic understanding and parental attitude are significant barriers to advance care discussions (ACD) for children with life-threatening conditions, according to a study published online March 5 in Pediatrics.

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Retinol Supplementation May Lower Melanoma Risk

MONDAY, March 5 (HealthDay News) -- Retinol supplementation is associated with a lower risk of melanoma, according to research published online March 1 in the Journal of Investigative Dermatology.

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Pap Smears Increase Cervical Cancer Survival

FRIDAY, March 2 (HealthDay News) -- Women whose cervical cancers are detected by cervical smears are much more likely to survive than women whose cancers are symptomatic, according to a study published online March 1 in BMJ.

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Device Stratifies Sickle Cell Disease Severity

FRIDAY, March 2 (HealthDay News) -- A device that measures the resistance of blood flow after deoxygenation can differentiate patients with benign or severe sickle cell disease, according to a study published in the Feb. 29 issue of Science Translational Medicine.

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Complementary Meds Used by 17 Percent of Elderly With Cancer

FRIDAY, March 2 (HealthDay News) -- The prevalence of older people with cancer using complementary medications as they start a chemotherapy regimen is 17 percent, and is associated with less advanced disease and higher functional status, according to a study published online Feb. 22 in Cancer.

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Vandetanib Doesn't Up Survival in Non-Small-Cell Lung Cancer

THURSDAY, March 1 (HealthDay News) -- Vandetanib does not improve overall survival for patients who have received previous treatment for advanced non-small-cell lung cancer (NSCLC), according to a study published online Feb. 27 in the Journal of Clinical Oncology.

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Hypoferremia Predicts Treatment Response to IFN-α

THURSDAY, March 1 (HealthDay News) -- For patients with hepatitis C virus (HCV), hepcidin, a regulator of iron homeostasis, is induced following a single dose of pegylated interferon-α (PEG-IFNα), and may be a surrogate marker of immediate efficacy of IFN-α, according to a study published online Feb. 15 in Hepatology.

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Specialties Hematology & Oncology

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