Colorectal Cancer Death Risk Down in Bowel Disease

-- Jeff Muise

Tuesday, May 12, 2009

TUESDAY, May 12 (HealthDay News) -- The incidence of colorectal cancer (CRC) in people with inflammatory bowel disease (IBD) has not significantly changed in recent decades, but the risk of CRC death has dropped substantially, according to a study published in the May issue of Gastroenterology.

Sverre Soderlund, M.D., of Stockholm Soder Hospital in Sweden, and colleagues assembled data on a large cohort of 7,607 patients with IBD, diagnosed between 1954 and 1989. The researchers then tracked the cohort looking for the incidence of CRC and resulting mortality through 2004. They calculated relative risks for CRC incidence and mortality using Poisson regression, adjusting for age, sex, IBD severity, and time since IBD diagnosis. The data was compared with standardized CRC incidence and mortality ratios for the general population.

In follow-up, the researchers note that there were 188 cases of CRC and 92 CRC deaths among the 7,607 IBD patients. CRC risk remained relatively consistent in the IBD cohort over the decades; however, CRC mortality risk dramatically decreased over the time period.

"Over the past 35 years, the risk of diagnosis of CRC in patients with IBD has not declined significantly, but the risk of dying of CRC has decreased substantially," the authors conclude.

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Specialties Cardiology
Diabetes & Endocrinology
Internal Medicine
Family Practice

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