Wednesday, January 28, 2009
WEDNESDAY, Jan. 28 (HealthDay News) -- Premenopausal women with early-stage endometrial cancer do not have higher odds of five-year survival if they undergo oophorectomy in addition to hysterectomy, according to study findings published online Jan. 26 in the Journal of Clinical Oncology.
Jason D. Wright, M.D., of Columbia University College of Physicians and Surgeons in New York City, and colleagues analyzed data on 3,269 women aged 45 years and younger who were treated for stage I endometrial cancer, of whom 402 (12 percent) did not have an oophorectomy as part of their treatment.
Cancer-specific and overall survival odds were the same for patients who did and did not undergo oophorectomy, the investigators found. Even when patients who received pelvic radiotherapy were excluded, the finding remained the same, the researchers report.
"Our findings suggest that ovarian preservation in premenopausal women with early-stage, low-grade endometrial cancer may be safe and not associated with an increased risk of cancer-related mortality," the authors write. "Given the potential consequences of surgical menopause, further research to examine the safety of ovarian conservation for young women with early-stage endometrial cancer is clearly warranted. At present, the long-term risks and benefits of ovarian preservation should be carefully discussed with young women with endometrial cancer before hysterectomy."
Diabetes & Endocrinology
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