Cancer News
OncoLink Cancer News - HealthDay


June 2012 Briefing - Hematology & Oncology

Monday, July 2, 2012 (Last Updated: 07/03/2012)

Here are what the editors at HealthDay consider to be the most important developments in Hematology & Oncology for June 2012. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Nelarabine Plus Chemo Viable in Children With T-Cell ALL

FRIDAY, June 29 (HealthDay News) -- Treatment of children with newly-diagnosed T-cell acute lymphoblastic leukemia (T-ALL) with nelarabine, in addition to an intensive Berlin-Frankfurt-Münster (BFM) 86-based chemotherapy regimen, is feasible and safe, according to a study published online June 25 in the Journal of Clinical Oncology.

Abstract
Full Text (subscription or payment may be required)

Aspirin Use Linked to Reduced Risk of Barrett's Esophagus

THURSDAY, June 28 (HealthDay News) -- Current aspirin users have a significantly reduced risk of being diagnosed with Barrett's esophagus (BE) on first endoscopy compared with nonusers, according to a study published in the July issue of Clinical Gastroenterology and Hepatology.

Abstract
Full Text (subscription or payment may be required)

Supreme Court Upholds Health Care Reform Law

THURSDAY, June 28 (HealthDay News) -- The U.S. Supreme Court voted June 28 to uphold the constitutionality of the Patient Protection and Affordable Care Act (PPACA), which has been the subject of debate and multiple lawsuits since its 2010 inception.

More Information

Risk of Second Primary Melanoma Up in Pediatric Patients

THURSDAY, June 28 (HealthDay News) -- Pediatric patients diagnosed with an invasive cutaneous melanoma have nearly double the relative risk of developing a subsequent primary melanoma, compared with adults, according to a study published online June 20 in the British Journal of Dermatology.

Abstract
Full Text (subscription or payment may be required)

Nomogram Developed to Estimate Early Breast Cancer Survival

WEDNESDAY, June 27 (HealthDay News) -- A nomogram has been developed to predict five- and 10-year mastectomy-free survival (MFS) in older women with early breast cancer and estimate the predicted benefit of radiation therapy (RT) following conservative surgery (CS), according to research published online June 25 in the Journal of Clinical Oncology.

Abstract
Full Text (subscription or payment may be required)
Editorial

Hospice Visit Number Affects Ability to Die at Home

WEDNESDAY, June 27 (HealthDay News) -- Hospice patients with cancer are more likely to be able to die in the setting of their choice if they receive at least one hospice visit per day during the first four days of hospice care, according to research published online June 25 in the Journal of Clinical Oncology.

Abstract
Full Text (subscription or payment may be required)

Duplicate Payments by Federal Government Increasing

WEDNESDAY, June 27 (HealthDay News) -- The federal government spends a substantial and increasing amount on individuals who are dually enrolled in separate managed care programs (the Veterans Affairs health care system [VA] and Medicare Advantage plan [MA]), according to a study published online June 26 in the Journal of the American Medical Association to coincide with presentation at the Annual Research Meeting of AcademyHealth, held from June 24 to 26 in Orlando, Fla.

Abstract
Full Text
More Information

Limited Radiation Acceptable in Pediatric Hodgkin's Lymphoma

TUESDAY, June 26 (HealthDay News) -- For patients with favorable-risk Hodgkin's lymphoma who achieve a complete early response to chemotherapy with vinblastine, Adriamycin (doxorubicin), methotrexate, and prednisone (VAMP), two-year event-free survival rates are high with limited use of radiotherapy, according to a study published in the June 27 issue of the Journal of the American Medical Association.

Abstract
Full Text
Editorial

Use of Electronic Records Tied to Fewer Malpractice Claims

TUESDAY, June 26 (HealthDay News) -- Use of electronic health records (EHRs) is associated with fewer medical malpractice claims among physicians from multiple surgical and medical specialties, according to a research letter published online June 25 in the Archives of Internal Medicine.

Full Text

Recreational Physical Activity Reduces Breast Cancer Risk

MONDAY, June 25 (HealthDay News) -- During the reproductive and postmenopausal years, recreational physical activity (RPA) at any intensity level is associated with reduced breast cancer risk, according to a study published online June 25 in Cancer.

Abstract
Full Text (subscription or payment may be required)

Advanced BRAF V600E Melanoma Responds to Dabrafenib

MONDAY, June 25 (HealthDay News) -- Patients with BRAF V600E-mutated metastatic melanoma treated with dabrafenib, an inhibitor of mutated BRAF, have significantly improved progression-free survival compared to those treated with dacarbazine, according to a study published online June 25 in The Lancet.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

No Therapy for ~20 Percent With Stage IV Solid Tumors

FRIDAY, June 22 (HealthDay News) -- About 20 percent of patients diagnosed with stage IV metastatic solid tumors do not receive anticancer treatment, according to a study published online June 15 in Cancer.

Abstract
Full Text (subscription or payment may be required)

Similar Outcomes for Robot-Aided, Conventional Nephrectomy

FRIDAY, June 22 (HealthDay News) -- Robot-assisted and conventional laparoscopic partial nephrectomies have similar outcomes and complication rates, according to a study published in the July issue of The Journal of Urology.

Abstract
Full Text (subscription or payment may be required)

Increased Sick Leave Rates for Long-Term Cancer Survivors

FRIDAY, June 22 (HealthDay News) -- Five years after a cancer diagnosis, employed cancer survivors have a higher sick leave rate compared with prior to their diagnosis, according to a study published in the June issue of the Journal of Cancer Survivorship.

Abstract
Full Text (subscription or payment may be required)

Reduced Efficacy for CRC Screenings Done by Non-GI Docs

FRIDAY, June 22 (HealthDay News) -- Having interval colorectal cancer (CRC) colonoscopy screenings performed by nongastroenterologists compared with gastroenterologists (GIs) results in a noticeable reduction in the long-term CRC prevention rate, according to research published online June 15 in Cancer.

Abstract
Full Text (subscription or payment may be required)

Half of Residents Report Working While Sick

THURSDAY, June 21 (HealthDay News) -- About half of residents have worked while sick, with many reporting feeling obligated to colleagues and patients, according to a research letter published online June 18 in the Archives of Internal Medicine.

Full Text

IVC Filters Confirmed Effective for Patients at Embolism Risk

THURSDAY, June 21 (HealthDay News) -- Inferior vena cava (IVC) filters are safe for use in patients at higher risk for venous thromboembolic events (VTEs) while undergoing major spinal surgery, according to research published in the June issue of the Journal of Spinal Disorders & Techniques.

Abstract
Full Text (subscription or payment may be required)

Accuracy of Melanoma Detection Up in Specialized Clinics

WEDNESDAY, June 20 (HealthDay News) -- From 1998 to 2007, the accuracy of melanoma detection improved in specialized but not non-specialized clinical settings, according to research published in the July issue of the Journal of the American Academy of Dermatology.

Abstract
Full Text (subscription or payment may be required)

Diabetes Linked to Increased Cause-Specific Mortality

WEDNESDAY, June 20 (HealthDay News) -- Diabetes is linked with a significantly increased risk of death from many diseases, including specific cancers, in both men and women, according to a study published online June 14 in Diabetes Care.

Abstract
Full Text (subscription or payment may be required)

Periodontitis Linked to HPV-Positive Head, Neck Tumors

WEDNESDAY, June 20 (HealthDay News) -- For patients with head and neck squamous cell carcinoma (HNSCC) there is an increased risk of human papillomavirus (HPV)-positive tumors among those with a history of periodontitis, according to a study published online June 18 in the Archives of Otolaryngology -- Head & Neck Surgery.

Abstract
Full Text (subscription or payment may be required)

Smoking Increases Risk of Squamous Cell Carcinoma

WEDNESDAY, June 20 (HealthDay News) -- Smoking increases the risk of cutaneous squamous cell carcinoma but is not associated with an increased risk of basal cell carcinoma or nonmelanoma skin cancer, according to a systematic review and meta-analysis published online June 18 in the Archives of Dermatology.

Abstract
Full Text
Editorial

Tumor-Infiltrating Lymphocyte Grade IDs Melanoma Survival

WEDNESDAY, June 20 (HealthDay News) -- Tumor-infiltrating lymphocyte (TIL) grade is an independent predictor of melanoma-specific survival and sentinel lymph node (SLN) status in patients with localized primary cutaneous melanoma, according to a study published online June 18 in the Journal of Clinical Oncology.

Abstract
Full Text (subscription or payment may be required)

Hepatitis B Screening Before Chemo Deemed Cost-Effective

WEDNESDAY, June 20 (HealthDay News) -- Universal hepatitis B virus (HBV) screening before chemotherapy for lymphoma reduces costs in most settings, according to a study published online June 18 in the Journal of Clinical Oncology.

Abstract
Full Text

Abnormal Fusion Transcript Linked to Prostate Cancer

TUESDAY, June 19 (HealthDay News) -- A fusion transcript generated in prostate cancers without chromosomal rearrangement is associated with prostate cancer growth and disease progression, according to a study published online June 19 in Cancer Discovery.

Abstract
Full Text (subscription or payment may be required)

Germ-Line BRCA1/2 Testing Recommended in Ovarian Cancer

TUESDAY, June 19 (HealthDay News) -- Due to the potential survival and treatment response implications of BRCA mutation status, it is recommended that germ-line BRCA1/2 testing be offered to all women diagnosed with nonmucinous ovarian carcinoma, regardless of family history, according to research published online June 18 in the Journal of Clinical Oncology.

Abstract
Full Text (subscription or payment may be required)

Multiple Tumor Zones Should Be Sampled in Breast Cancer

MONDAY, June 18 (HealthDay News) -- For any given patient with breast cancer, the expression of microRNAs (miRNAs), which has been linked to tumor development and progression, varies greatly within the same tumor and lymph node metastases, according to a study published online June 18 in The Journal of Molecular Diagnostics.

Abstract
Full Text (subscription or payment may be required)

JAK3 Mutations ID'd in About One-Third of T-Cell Lymphomas

FRIDAY, June 15 (HealthDay News) -- Approximately one-third of patients with natural killer/T-cell lymphoma (NKTCL) harbor somatic-activating Janus kinase 3 (JAK3) mutations, according to a study published online June 15 in Cancer Discovery.

Abstract
Full Text (subscription or payment may be required)

Younger Adult Cancer Survivors in Poorer Health Than Peers

FRIDAY, June 15 (HealthDay News) -- Adolescent and young adult (AYA) cancer survivors -- those ages 15 to 29 years at their first diagnosis -- report higher rates of unhealthy behaviors, chronic medical conditions, and less access to health care than respondents who never had cancer, and may be at risk for poor long-term health outcomes, according to a study published online June 11 in Cancer.

Abstract
Full Text (subscription or payment may be required)

Weight Loss Linked to Reduced Cancer Incidence, Mortality

FRIDAY, June 15 (HealthDay News) -- Weight loss, particularly intentional weight loss, is associated with a reduced incidence of cancer and mortality, especially for women and for obesity-related cancers, according to a review published online June 4 in Obesity Reviews.

Abstract
Full Text (subscription or payment may be required)

Testosterone Therapy Does Not Up Prostate Cancer Incidence

FRIDAY, June 15 (HealthDay News) -- Testosterone replacement therapy (TRT) appears to be safe and does not increase the incidence of prostate cancer, according to a study published online June 6 in The Journal of Sexual Medicine.

Abstract
Full Text (subscription or payment may be required)

Number of Cancer Survivors May Reach ~18 Million by 2022

THURSDAY, June 14 (HealthDay News) -- Based on current trends and treatment patterns, the estimated number of cancer survivors in the United States is likely to increase to nearly 18 million by Jan. 1, 2022, according to a report published online June 14 in CA: A Cancer Journal for Clinicians.

Abstract
Full Text

CDC: Preventive Health Services Underused Before 2010

THURSDAY, June 14 (HealthDay News) -- Prior to 2010, only about half of all U.S. adults received key preventive health services, according to a report published in the June 15 supplement of the U.S. Centers for Disease Control and Prevention's Morbidity & Mortality Weekly Report.

More Information

Pre-Op Breast Pain in ~28 Percent of Breast Cancer Patients

THURSDAY, June 14 (HealthDay News) -- More than a quarter of women about to undergo breast cancer surgery experience breast pain, with genetic polymorphisms in inflammatory cytokines correlating with pain, according to a study published in the May issue of The Journal of Pain.

Abstract
Full Text (subscription or payment may be required)

New Peri-Op Approach Accurately IDs Melanoma in Nail Matrix

THURSDAY, June 14 (HealthDay News) -- Intraoperative reflectance confocal microscopy (RCM) can be used to diagnose melanonychia striata in the nail matrix, according to a study published online June 7 in the British Journal of Dermatology.

Abstract
Full Text (subscription or payment may be required)

Fatal Airway Necrosis Noted After Stereotactic Body Radiation

WEDNESDAY, June 13 (HealthDay News) -- A woman who was treated with stereotactic body-radiation therapy (SBRT) for two non-metastasized non-small-cell lung cancers died from fatal central-airway necrosis, according to a case report published in the June 14 issue of the New England Journal of Medicine.

Full Text

Poor Oral Hygiene Found Predictive of Cancer Mortality

WEDNESDAY, June 13 (HealthDay News) -- Poor oral hygiene, as determined by an increased amount of dental plaque, is a significant and independent predictor of cancer-related death, according to a study published online June 11 in BMJ Open.

Abstract
Full Text

Changes in Tumor Size by RECIST Correlate With Survival

WEDNESDAY, June 13 (HealthDay News) -- RECIST categories used to quantify tumor changes during exposure to anticancer therapies correlate well with overall survival (OS) but reflect a more linear continuum without clear inflection points, according to a study published online June 11 in the Journal of Clinical Oncology.

Abstract
Full Text (subscription or payment may be required)

Cannabinoid Formulation Benefits Opioid-Refractory Pain

WEDNESDAY, June 13 (HealthDay News) -- A novel cannabinoid formulation, nabiximols, is safe and effective for patients with advanced cancer and opioid-refractory pain, especially at a low-dose, according to a study published in the May issue of The Journal of Pain.

Abstract
Full Text (subscription or payment may be required)

Advanced Imaging, Radiation Exposure Up Over Last Decade

TUESDAY, June 12 (HealthDay News) -- From 1996 to 2010 there was an increase in the use of advanced diagnostic imaging and associated radiation exposure within integrated health care systems, according to a study published in the June 13 issue of the Journal of the American Medical Association.

Abstract
Full Text
Editorial

Perjeta Approved for Advanced Breast Cancer

TUESDAY, June 12 (HealthDay News) -- Perjeta (pertuzumab) has been approved by the U.S. Food and Drug Administration to treat people with HER2-positive late-stage breast cancer, the agency said in a news release.

this approval

Gender Gap Exists in Physician Researchers' Salaries

TUESDAY, June 12 (HealthDay News) -- A survey of mid-career academic physician researchers shows that gender differences in salary exist even after adjusting for differences in specialty, institutional characteristics, academic productivity, academic rank, and work hours, according to a study published in the June 13 issue of the Journal of the American Medical Association.

Abstract
Full Text

Breast Cancer Incidence Down With Metformin Use in Diabetes

TUESDAY, June 12 (HealthDay News) -- For postmenopausal women with diabetes, use of metformin is associated with lower incidence of invasive breast cancer, according to a study published online June 11 in the Journal of Clinical Oncology.

Abstract
Full Text (subscription or payment may be required)
Editorial

Gene Mutations May Predict Breast CA Treatment Response

MONDAY, June 11 (HealthDay News) -- Genetic mutations present in women with breast cancer may be able to predict whether the tumor will respond to treatment, according to a study published online June 10 in Nature.

Full Text

Many PCPs Recommend Colorectal Cancer Screening in Elderly

MONDAY, June 11 (HealthDay News) -- A substantial portion of primary care physicians (PCPs) recommend screening elderly patients with advanced cancer for colorectal cancer (CRC), according to a study published online June 1 in the Journal of General Internal Medicine.

Abstract
Full Text (subscription or payment may be required)

Marker Helps Predict Thrombotic Risk of Hormonal Contraceptives

FRIDAY, June 8 (HealthDay News) -- For women taking hormonal contraceptives, sex hormone-binding globulin (SHBG) is a useful marker to estimate the risk of venous thrombosis, according to research published in the June issue of the Journal of Thrombosis and Haemostasis.

Abstract
Full Text (subscription or payment may be required)

Prevalence, Predictors of Interval Colorectal Cancer ID'd

FRIDAY, June 8 (HealthDay News) -- A variety of procedural and biologic factors contribute to the development of interval colorectal cancers, seen in 7.2 percent of Medicare beneficiaries, according to a study published in the June 15 issue of Cancer.

Abstract
Full Text (subscription or payment may be required)

Higher Risk of VTE in CKD Surgical Patients on Enoxaparin

FRIDAY, June 8 (HealthDay News) -- For patients with chronic kidney disease (CKD) who undergo total hip replacement (THR), the rate of major venous thromboembolism (VTE) is significantly higher in those treated with enoxaparin compared to those treated with desirudin, according to a study published online June 4 in the Journal of Thrombosis and Haemostasis.

Abstract
Full Text (subscription or payment may be required)

Venous Thromboembolism Up in Adult Hospitalizations

THURSDAY, June 7 (HealthDay News) -- Every year, more than half a million hospitalized U.S. adults acquire venous thromboembolism (VTE), a growing public health concern that is often preventable, according to research published in the June 8 issue of the U.S. Centers for Disease Control and Prevention's Morbidity & Mortality Weekly Report.

Full Text

CT Scans Up Risk of Leukemia, Brain Tumors in Young

THURSDAY, June 7 (HealthDay News) -- For children and young adults, radiation from computed tomography (CT) scans is linked to an increased risk of leukemia and brain tumors, although the absolute risks are small, according to a study published online June 7 in The Lancet.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Beta-Carotene Safe During Prostate Cancer Treatment

THURSDAY, June 7 (HealthDay News) -- The use of the antioxidant beta-carotene during radiation therapy treatment for prostate cancer is not associated with an increase in prostate cancer deaths or metastases, according to research published in the May issue of the International Journal of Radiation Oncology*Biology*Physics.

Abstract
Full Text (subscription or payment may be required)

Vismodegib Has Antitumor Activity in Basal Cell Carcinoma

WEDNESDAY, June 6 (HealthDay News) -- A small-molecule inhibitor of the hedgehog pathway, vismodegib, is associated with tumor response in patients with metastatic or locally advanced basal cell carcinoma (BCC); and vismodegib is efficacious for preventing and treating BCCs in patients with basal cell nevus syndrome, according to two studies published in the June 7 issue of the New England Journal of Medicine.

Full Text - Sekulic (subscription or payment may be required)
Full Text - Tang (subscription or payment may be required)
Editorial (subscription or payment may be required)

Circulating Tumor Cells Tied to Poor Prognosis in Breast Cancer

WEDNESDAY, June 6 (HealthDay News) -- For chemo-naive patients with non-metastatic breast cancer, the presence of one or more circulating tumor cells is associated with decreased progression-free and overall survival, according to a study published online June 6 in The Lancet Oncology.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Aspirin Ups Risk of Bleeding in All But Diabetes Patients

TUESDAY, June 5 (HealthDay News) -- Aspirin use is associated with an increased risk of major bleeding, while patients with diabetes have a high risk of bleeding, independent of aspirin use, according to a study published in the June 6 issue of the Journal of the American Medical Association.

Abstract
Full Text
Editorial

Gender Gap in Reproductive Preservation in Cancer Patients

TUESDAY, June 5 (HealthDay News) -- A gender gap exists in the manner in which young adult cancer patients are presented with fertility preservation options, with women reporting fewer discussions of future reproductive choices, according to a study published online May 30 in BJOG: An International Journal of Obstetrics and Gynaecology.

Abstract
Full Text (subscription or payment may be required)

Acellular Dermal Matrix Safe, Useful in Breast Reconstruction

FRIDAY, June 1 (HealthDay News) -- Acellular dermal matrices provide good outcomes for patients undergoing breast reconstruction following mastectomy, but the human AlloDerm matrix has a higher seroma rate than porcine Strattice matrix, according to a study published in the June issue of Plastic and Reconstructive Surgery.

Full Text

Global Cancer Incidence Set to Top 20 Million Per Year by 2030

FRIDAY, June 1 (HealthDay News) -- Assuming current trends continue, the global incidence of all-cancer cases is set to increase to more than 20 million per year by 2030, according to a study published online June 1 in The Lancet Oncology.

Abstract
Full Text (subscription or payment may be required)

Pioglitazone Use Ups Bladder Cancer Risk in Type 2 Diabetes

FRIDAY, June 1 (HealthDay News) -- For patients with type 2 diabetes, use of the oral hypoglycemic agent pioglitazone correlates with an increased risk of bladder cancer, with the risk increasing with duration of use, according to a study published online May 31 in BMJ.

Full Text
Editorial (subscription or payment may be required)

Specialties Hematology & Oncology

Copyright © 2012 ScoutNews, LLC. All rights reserved.


I Wish You Knew

HPV is now one of the main risk factors for head & neck cancers

View More







OncoLink OncoPilot

Facing a new cancer diagnosis or changing the course of your current treatment? Let our cancer nurses help you through!

Learn More