Cancer News
OncoLink Cancer News - HealthDay


Gene Subnetworks Predict Risk of Leukemia Progression

Friday, August 3, 2012 (Last Updated: 08/06/2012)

FRIDAY, Aug. 3 (HealthDay News) -- Subnetworks of interacting genes can predict the risk of disease progression requiring treatment in patients with chronic lymphocytic leukemia, according to a study published online July 26 in Blood.

Han-Yu Chuang, Ph.D., from the University of California San Diego in La Jolla, and colleagues performed a subnetwork-based analysis of gene expression profiles to determine the risk of disease progression in 130 patients with chronic lymphocytic leukemia.

The researchers identified 38 prognostic subnetworks that predicted the likelihood of disease progression requiring treatment from the date the sample was collected; this prediction was then validated in two independent groups. The prognostic subnetworks were found to be more accurate than established markers. For patients classified at diagnosis as having aggressive disease there was reduced divergence in gene expression over time, compared to those with indolent disease. Levels of expression varied over time, but increased similarity was noted at later time points before therapy.

"As such, these results have implications for understanding cancer evolution and for the development of novel treatment strategies for patients with chronic lymphocytic leukemia," Chuang and colleagues conclude.

Two authors were partially supported by grants from Pfizer and Agilent Labs. One author is an employee of Roche Molecular Systems and another is an employee of MLL Münchner Leukämielabor.

Abstract
Full Text (subscription or payment may be required)

Specialties Hematology & Oncology
Psychiatry
Internal Medicine
Pathology

Copyright © 2012 HealthDay. All rights reserved.


I Wish You Knew

Common myths about pain medication and pain control

View More



Blogs and Web Chats

OncoLink Blogs give our readers a chance to react to and comment on key cancer news topics and provides a forum for OncoLink Experts and readers to share opinions and learn from each other.




OncoLink OncoPilot

Facing a new cancer diagnosis or changing the course of your current treatment? Let our cancer nurses help you through!

Learn More