Cancer News
OncoLink Cancer News - HealthDay

Study Supports IL16 Role in Prostate CA in African-Americans

Wednesday, September 12, 2012 (Last Updated: 09/13/2012)

WEDNESDAY, Sept. 12 (HealthDay News) -- In African-Americans, IL16 polymorphisms appear to play a role in prostate cancer susceptibility, according to research published online Aug. 24 in Cancer Epidemiology, Biomarkers & Prevention.

To test for allelic association, Ken Batai, from the University of Illinois at Chicago, and colleagues conducted a study using 2,257 genotyped and imputed single nucleotide polymorphisms (SNPs) spanning the interleukin (IL)-16 gene in samples obtained from 605 African-Americans with prostate cancer. A technique called imputation, a type of statistical extrapolation, was used to identify new patterns of association and to narrow the search for polymorphisms.

The researchers found that a cluster of IL16 SNPs was significantly associated with prostate cancer risk in African-Americans. A total of three independent loci within IL16 were identified that were associated with prostate cancer risk in this patient population. One in particular, rs7175701, was predicted to influence IL16 expression and, potentially, the expression of other cancer-related genes.

"Our findings are significant given that there has been limited focus on the role of IL16 genetic polymorphisms on prostate cancer risk in African-Americans. To our knowledge, this is the first study that demonstrated the association of these variants with cancer in African-descent populations," the authors write. "Identifying genetic variants affecting the expression and interaction of IL16 and other gene expressed in tumor cells is important for understanding the role of IL16 in tumor growth."

Full Text (subscription or payment may be required)

Specialties OBGYN & Women's Health
Hematology & Oncology
Family Practice

Copyright © 2012 HealthDay. All rights reserved.

I Wish You Knew

The role of cancer biology and genetics in cancer

View More

Blogs and Web Chats

OncoLink Blogs give our readers a chance to react to and comment on key cancer news topics and provides a forum for OncoLink Experts and readers to share opinions and learn from each other.

OncoLink OncoPilot

Facing a new cancer diagnosis or changing the course of your current treatment? Let our cancer nurses help you through!

Learn More