Tuesday, October 2, 2012 (Last Updated: 10/03/2012)
Sunil Verma, M.D., from the Sunnybrook Odette Cancer Centre in Toronto, and colleagues randomly assigned 991 patients with advanced HER2-positive breast cancer to T-DM1 or lapatinib plus capecitabine. Patients had previously been treated with trastuzumab and a taxane.
The researchers found that the T-DM1 group had significantly longer median progression-free survival (9.6 versus 6.4 months; hazard ratio for progression or death from any cause, 0.65) and significantly longer median overall survival (30.9 versus 25.1 months; hazard ratio of death from any cause, 0.68). The T-DM1 group had lower rates of grade 3 or 4 adverse events (41 versus 57 percent). This group also had a significantly higher objective response rate and a longer median duration of response.
"In conclusion, our study shows that T-DM1 has therapeutic potential, across a heterogeneous population of patients, for the treatment of advanced, HER2-positive breast cancer that has progressed during or after treatment with trastuzumab and a taxane," Verma and colleagues conclude.
The study was funded by Hoffmann-La Roche/Genentech, the manufacturer of trastuzumab emtansine; several authors disclosed financial ties to pharmaceutical companies, including Hoffmann-La Roche/Genentech.
Hematology & Oncology
Copyright © 2012 HealthDay. All rights reserved.