Tuesday, May 26, 2009
TUESDAY, May 26 (HealthDay News) -- The age at which prostate cancer is diagnosed has declined in recent decades, according to research published online May 22 in Cancer.
Daniel W. Lin, M.D., of the University of Washington in Seattle, and colleagues analyzed data from the National Cancer Institute's Surveillance, Epidemiology, and End Results database on more than 300,000 men ages 35 to 74 years who were diagnosed with prostate cancer between 1988 and 2003.
The researchers found that the proportion of men who were 55 years old or younger at diagnosis increased from 2.3 percent at the beginning of this period to 9 percent toward the end. Over this time, median age at diagnosis fell from 72 to 68 years. Younger men were less likely to be diagnosed with high-grade tumors, but were also less likely to be diagnosed with disease confined to the prostate, the authors note.
"Our finding that high-grade cancer was associated with greater than 25 percent cancer-related mortality at 10 years in men aged less than 55 emphasizes the significant incidence of disease-related morbidity in this group of men. These data provide a strong argument for the need to consider multimodality therapy for young men with high-risk disease and to support the ongoing neoadjuvant and adjuvant studies of systemic therapies, which could improve the efficacy of local therapy and the chance of achieving a cure for these men," the authors write.
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