Cancer News
OncoLink Cancer News - HealthDay


Tricuspid Regurgitant Jet Velocity Up in Childhood Cancer Survivors

Thursday, January 17, 2013 (Last Updated: 01/18/2013)

THURSDAY, Jan. 17 (HealthDay News) -- About one-quarter of adult survivors of childhood cancer who received chest-directed radiation therapy (RT) have increased tricuspid regurgitant jet velocity (TRV), according to research published online Jan. 7 in the Journal of Clinical Oncology.

Gregory T. Armstrong, M.D., of St. Jude Children's Research Hospital in Memphis, Tenn., and colleagues conducted a cross-sectional assessment involving 498 adult survivors of childhood cancer (median age, 38.0 years; median time from primary diagnosis, 27.3 years) to examine the prevalence of pulmonary hypertension, a late effect of cancer therapy.

The researchers found that 25.2 percent of survivors who received chest-directed RT and 30.8 percent of those who received more than 30 Gy had increased TRV. Increased TRV correlated with increasing dose of RT, body mass index more than 40 kg/m², and aortic valve regurgitation, in multivariate analysis. The odds of severe functional limitation on a six-minute walk were significantly increased for those with TRV more than 2.8 m/s versus those with a TRV ≤2.8 ms/s (odds ratio, 5.20).

"In conclusion, we identified an increased prevalence of TRV more than 2.8 m/s, which may indicate pulmonary hypertension, in a large, well-characterized population of childhood cancer survivors," the authors write. "Increased risk was associated with chest-directed RT exposure, potentially mediated through both cardiac and pulmonary dysfunction."

Abstract
Full Text (subscription or payment may be required)

Specialties Hematology & Oncology
Nursing
Pediatrics
Family Practice
Cardiology

Copyright © 2013 HealthDay. All rights reserved.


I Wish You Knew

Pain management at the end of life

View More



Blogs and Web Chats

OncoLink Blogs give our readers a chance to react to and comment on key cancer news topics and provides a forum for OncoLink Experts and readers to share opinions and learn from each other.




OncoLink OncoPilot

Facing a new cancer diagnosis or changing the course of your current treatment? Let our cancer nurses help you through!

Learn More