Cancer News
OncoLink Cancer News - HealthDay

Low-Risk Bladder Cancer Rarely Progresses to Muscle Invasion

Tuesday, March 5, 2013 (Last Updated: 03/06/2013)

TUESDAY, March 5 (HealthDay News) -- Low-risk bladder cancer rarely progresses to muscle invasion but is associated with an increased risk of disease-specific mortality compared with matched populations, according to research published in the March issue of The Journal of Urology.

Kate D. Linton, of the University of Sheffield in the United Kingdom, and colleagues examined the risk of disease-specific mortality in 699 patients with primary, low-risk, noninvasive (G1pTa) bladder cancer who were followed for a median of 61 months.

During follow-up, the researchers found that 17 patients died of bladder cancer, including 13 of 14 who displayed progression to muscle invasion and four of 19 who exhibited grade progression to high-grade, nonmuscle invasive disease. Tumor weight and low-grade dysplasia in the initial resection specimen were found to be significantly associated with disease-specific mortality. In these patients, the rate of disease-specific mortality was five times higher than in age and gender matched general populations.

"The rate of progression to muscle invasion and disease-specific mortality in patients with low-risk bladder cancer is low but higher than in the general population," the authors write. "Current surveillance regimens failed to detect advancing disease in time to alter its natural history. While a randomized trial is necessary to robustly confirm our findings, these observations question current surveillance regimens."

One author disclosed a financial tie to GlaxoSmithKline; the study was partially supported by a GlaxoSmithKline SK Clinician Scientist fellowship.

Full Text (subscription or payment may be required)

Specialties Hematology & Oncology

Health News Copyright © 2013 HealthDay. All rights reserved.

I Wish You Knew

The importance of survivorship care

View More

Blogs and Web Chats

OncoLink Blogs give our readers a chance to react to and comment on key cancer news topics and provides a forum for OncoLink Experts and readers to share opinions and learn from each other.

OncoLink OncoPilot

Facing a new cancer diagnosis or changing the course of your current treatment? Let our cancer nurses help you through!

Learn More