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USPSTF: BRCA Testing for Women With Family History

Tuesday, April 2, 2013 (Last Updated: 04/03/2013)

TUESDAY, April 2 (HealthDay News) -- The U.S. Preventive Services Task Force (USPSTF) recommends that BRCA1 and BRCA2 genetic testing be limited to women whose family histories are associated with an increased likelihood of having BRCA mutations.

Researchers from the USPSTF reviewed the evidence to assess whether genetic counseling and testing could be effective for identifying women who are most likely to have mutations in BRCA1 and BRCA2 genes. Noting that current tests often yield inconclusive results, the evidence suggests that women whose family histories are not associated with an increased risk for BTRCA1 or BRCA2 mutations should not undergo genetic counseling or testing. Women who have family members with breast or ovarian cancer should undergo screening to identify whether their family history is associated with having BRCA mutations. Women who screen positive should be offered genetic counseling and, if indicated, should receive the test after adequate consideration of the pros and cons of testing.

The draft Recommendation Statement is available for comment from April 2 to April 29, 2013.

"At this point, scientific evidence only shows that BRCA1 and BRCA2 testing is beneficial for women who have reviewed their family history of breast or ovarian cancer with a primary care professional and discussed the pros and cons of the screening test with a trained genetic counselor," Task Force chair Virginia Moyer, M.D., M.P.H., said in a statement. "We hope that further research into ways to use genomic science, such as identifying women who have harmful BRCA genes but do not have a family history of cancer, could improve screening practices and even prevent some cancers."

Draft Recommendation Statement
Comment on Recommendations

Specialties Hematology & Oncology
OBGYN & Women's Health
Internal Medicine

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