Cancer News
OncoLink Cancer News - HealthDay


More Support for Surveillance in Low-Grade Prostate Cancer

Wednesday, August 14, 2013 (Last Updated: 08/15/2013)

WEDNESDAY, Aug. 14 (HealthDay News) -- Since the introduction of prostate-specific antigen (PSA) screening there has been a large reduction in advanced-stage cancers but only a modest drop in cancers with a high Gleason score, suggesting that patients with lower-grade disease do not progress to higher grade over time and may benefit from active surveillance, according to a study published in the Aug. 15 issue of Cancer Research.

Kathryn L. Penney, Sc.D., from Brigham and Women's Hospital in Boston, and colleagues compared the distribution of grade and clinical stage over time among 1,207 health professionals who were diagnosed with prostate cancer from 1982 to 2004, representing the pre-PSA and post-PSA screening eras, and treated with prostatectomy.

The researchers found that the percentage of advanced-stage cancers fell more than six-fold, from 19.9 percent (stage T3 or greater) from 1982 to 1993 to 3 percent (all stage T3) from 2000 to 2004. However, the percentage with a Gleason score of 8 or more fell only 30 percent over these periods, from 25.3 to 17.6 percent. There was a significant association noted between grade and stage by time period.

"As the dramatic shift in stage since the introduction of PSA screening was accompanied by a more modest shift in Gleason grade, these findings suggest that grade may be established early in tumor pathogenesis," Penney and colleagues conclude. "This has implications for the understanding of tumor progression and prognosis, and may help patients diagnosed with lower-grade disease feel more comfortable choosing active surveillance."

Abstract
Full Text (subscription or payment may be required)

Specialties OBGYN & Women's Health
Nursing
Family Practice

Copyright © 2013 HealthDay. All rights reserved.


I Wish You Knew

Understanding prostate cancer screening

View More



Blogs and Web Chats

OncoLink Blogs give our readers a chance to react to and comment on key cancer news topics and provides a forum for OncoLink Experts and readers to share opinions and learn from each other.




OncoLink OncoPilot

Facing a new cancer diagnosis or changing the course of your current treatment? Let our cancer nurses help you through!

Learn More