Tuesday, October 1, 2013 (Last Updated: 10/04/2013)
Amin Mirhadi, M.D., from the Cedars Sinai Medical Center in Los Angeles, and colleagues compared the effect of long-term versus short-term hormonal therapy using data from 133 patients with intermediate-risk prostate cancer enrolled in the RTOG 9202 trial. Seventy-four patients were treated with initial androgen deprivation only (STAD) and 59 received long-term adjuvant androgen deprivation (LTAD).
The researchers found that with a median follow-up of more than 11 years, 39 patients in the STAD group and 33 in the LTAD group were alive. Overall survival (OS) was not significantly different between the groups (10-year estimates, 61 percent in STAD versus 65 percent in LTAD; P = 0.53). Ten-year disease-specific survival (DSS) was not significantly different between the groups (96 percent in each group; P = 0.72), nor were prostate specific antigen failure rates (53 and 55 percent, respectively; P = 0.99).
"Most clinicians have felt that 'more was better' when it came to blocking testosterone in prostate cancer patients; however, results for the specific end points we focused on, OS and DSS, indicate that this was clearly not the case," Mirhadi said in a statement.
One author disclosed a financial relationship with Astellas.
Hematology & Oncology
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