Cancer News
OncoLink Cancer News - HealthDay


Cranial Irradiation in Pediatric Leukemia Unnecessary

-- Rick Ansorge

Wednesday, June 24, 2009

WEDNESDAY, June 24 (HealthDay News) -- In children newly diagnosed with acute lymphoblastic leukemia, effective risk-adjusted chemotherapy may eliminate the need for prophylactic cranial irradiation, according to a study published in the June 25 issue of the New England Journal of Medicine.

Ching-Hon Pui, M.D., of St. Jude Children's Research Hospital in Memphis, Tenn., and colleagues studied outcomes in a total of 498 patients, including 71 patients who previously would have received prophylactic cranial irradiation and 56 historical controls who did receive it.

Overall, the researchers found high rates of five-year event-free and overall survival (85.6 and 93.5 percent, respectively) and observed low five-year risks of isolated or any central nervous system relapse (2.7 and 3.9 percent, respectively). Compared to the 56 historical controls, they also found that the 71 patients who did not receive prophylactic cranial irradiation had significantly longer continuous complete remission.

"Our study showed that with intensification of systemic and intrathecal chemotherapy, prophylactic cranial irradiation can be totally omitted without compromising overall survival," the authors conclude.

Several authors reported relationships with the pharmaceutical and medical industry.

Abstract
Full Text (subscription or payment may be required)

Specialties Cardiology
Diabetes & Endocrinology
Internal Medicine
Family Practice

Copyright © 2009 ScoutNews, LLC. All rights reserved.


I Wish You Knew

The "C" word - why it's so scary and how can you cope?

View More



Blogs and Web Chats

OncoLink Blogs give our readers a chance to react to and comment on key cancer news topics and provides a forum for OncoLink Experts and readers to share opinions and learn from each other.




OncoLink OncoPilot

Facing a new cancer diagnosis or changing the course of your current treatment? Let our cancer nurses help you through!

Learn More