Tuesday, June 30, 2009
TUESDAY, June 30 (HealthDay News) -- In patients with stage I and IIA colon cancer, intensive postoperative surveillance is as beneficial as it is in late-stage patients, according to a study published online June 29 in the Journal of Clinical Oncology.
Vassiliki L. Tsikitis, M.D., of the Mayo Clinic in Rochester, Minn., and colleagues conducted a secondary analysis of data from the Clinical Outcomes of Surgical Therapy trial on 537 patients with early-stage disease and 254 patients with late-stage disease, in which five-year recurrence rates were 9.5 and 35.7 percent, respectively.
For early-stage and late-stage patients, the researchers found that salvage rates were 35.9 and 37 percent, respectively, and median survival after second surgery for recurrence was 51.2 and 35.8 months, respectively. They also found that both groups had similar sites of recurrence, and that there were no significant group differences in the rates at which recurrences were detected by carcinoembyronic antigen, computed tomography scan, chest X-ray, or colonoscopy.
"There can be little doubt that finding recurrences early brings benefit for patients of either stage," the authors write. "Only with additional economic studies will we be positioned to judge the broader question of cost to benefit ratio of early detection."
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