Personalized Therapy Feasible for Metastatic Breast Cancer
Friday, February 7, 2014 (Last Updated: 02/10/2014)
FRIDAY, Feb. 7, 2014 (HealthDay News) -- For patients with metastatic breast cancer, personalization of therapy is feasible, according to a study published online Feb. 7 in The Lancet Oncology.
Fabrice André, M.D., from INSERM Unit U981 in Paris, and colleagues recruited 423 patients with breast cancer with a metastasis accessible for biopsy from 18 centers. Four hundred seven biopsy samples were assessed using comparative genomic hybridization (CGH) array and Sanger sequencing on PIK3CA and AKT1. Therapeutic targets were selected based on the genomic alterations identified.
The researchers found that CGH array was feasible in 67 percent of patients, and Sanger sequencing was feasible in 70 percent. In 46 percent of patients, a targetable genomic alteration was identified, most frequently in PIK3CA, CCND1, and FGFR1 (25, 19, and 13 percent of identified genomic alterations, respectively). Rare genomic alterations (defined as occurring in less than 5 percent of the general population) were identified in 39 percent of patients with genomic tests available. Therapy could be personalized for 13 percent of the 423 patients (55 patients). Of the 43 patients who received personalized therapy, 9 percent had an objective response and 21 percent had stable disease for more than 16 weeks. Biopsy-related serious adverse events were reported in four enrolled patients.
"Personalization of medicine for metastatic breast cancer is feasible, including for rare genomic alterations," the authors write.
Several authors disclosed financial ties to the pharmaceutical industry.
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