Thursday, July 30, 2009
THURSDAY, July 30 (HealthDay News) -- A model developed to predict the 15-year risk of dying of prostate cancer after radical prostatectomy shows that the risk is very low, particularly in more recent patients treated in the era of widespread prostate-specific antigen (PSA) screening, according to a study published online July 27 in the Journal of Clinical Oncology.
Andrew J. Stephenson, M.D., from the Cleveland Clinic, and colleagues developed a model to predict the long-term risk of prostate cancer-specific mortality (PCSM) using clinical information and treatment outcome from 12,677 patients treated with radical prostatectomy.
The researchers determined that the 15-year PCSM was 12 percent and all-cause mortality was 38 percent. The predicted PCSM ranged from 5 to 38 percent, but was less than 5 percent in 96 percent of contemporary patients. Biopsy Gleason grade, PSA, and year of surgery predicted PCSM and were used to develop a nomogram to predict 15-year PCSM with a concordance index of 0.82.
"In summary, the long-term risk of PCSM among patients treated with radical prostatectomy in the era of widespread PSA screening is low, even for patients with adverse clinical features," Stephenson and colleagues conclude.
Diabetes & Endocrinology
Copyright © 2009 ScoutNews, LLC. All rights reserved.