Thursday, August 27, 2009
THURSDAY, Aug. 27 (HealthDay News) -- Human papillomavirus (HPV) infection, especially with HPV 16-18, may be associated with nearly half of the cases of penile carcinoma, according to a study published online Aug. 25 in the Journal of Clinical Pathology.
Carles Miralles-Guri, Ph.D., of the L' Hospitalet de Ll in Barcelona, Spain, and colleagues conducted a systematic review of 31 studies including 1,466 penile carcinomas.
The researchers found that 46.9 percent of the tumors tested positive for HPV. The most common types were HPV-16 (60.23 percent), HPV-18 (13.35 percent), and HPV-6/11 (8.13 percent), but the prevalence of other types such as HPV-31, HPV-45, and HPV-33 was low (about 1 percent). They also found that the most frequent HPV-related histological types were basaloid and warty squamous cell carcinomas, with prevalence rates of about 50 percent for keratinizing and non-keratinizing subtypes.
"The existence of a great variability among study designs, HPV DNA detection methods, and the difficulties of stratification of histology are important constraints when evaluating the prevalence of HPV," the authors conclude. "Systematic international studies are ongoing; they will probably help in reducing uncertainty and provide new evidence on the involvement of HPV in penile carcinoma."
Several authors reported financial relationships with the pharmaceutical industry.
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