Capn4 Linked to Metastasis and Invasion in Liver Cancer

-- Eric Metcalf

Friday, February 6, 2009

FRIDAY, Feb. 6 (HealthDay News) -- Overexpression of calpain small subunit 1 (Capn4) appears to play a role in invasion and metastasis following liver transplantation for hepatocellular carcinoma, according to research published in the February issue of Hepatology.

Dou-Sheng Bai, of Fudan University in Shanghai, China, and colleagues analyzed data from proteins collected from tumor cells of patients with hepatocellular carcinoma (HCC) that did or didn't recur following liver transplantation. The investigators found 52 proteins that were differently expressed in the recurrence group, including Capn4.

Capn4 was found to be overexpressed in those with recurrent cancer in another cohort of 40 HCC patients. The researchers also found that Capn4 expression was high in two types of cells with high metastatic potential, intermediate in cells with medium metastatic potential, and low in cells with minimal metastatic potential. Analysis of another 192 HCC samples found that roughly 94 percent of recurrent samples were highly positive for Capn4, and most non-recurrent samples were negatively expressed.

"The precise mechanism by which Capn4 promotes HCC cell migration and invasion remains to be elucidated, and further investigations are in process. Our study also yielded a list of proteins with a similar biological effect as Capn4, which might give a more profound insight into the mechanism of HCC recurrence and metastasis," the authors conclude.

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Diabetes & Endocrinology
Internal Medicine
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