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Biopsy Protocols Compared for Prostate Cancer Detection

-- Jeff Muise

Tuesday, September 29, 2009

TUESDAY, Sept. 29 (HealthDay News) -- Twelve-core and eight-core biopsies have similar prostate cancer detection rates for initial biopsy, but the additional transition cores provided in 12-core biopsy may be helpful in detecting missed cancers in repeat biopsies, according to a study in the October issue of the Journal of Urology.

Jean J.M.C.H. de la Rosette, M.D., of the University Hospital in Amsterdam, Netherlands, and colleagues randomized 269 patients with possible prostate cancer to receive biopsies using either an eight-core lateral (group one) or a 12-core (group two) transrectal ultrasound guided prostate biopsy protocol. If there was a negative initial biopsy, the patients underwent 12-core biopsy.

The researchers found no significant difference in cancer detection rate in groups one (34.1 percent) and two (38.3 percent). The median Gleason scores were similar in both groups for detected cancers. Of 109 patients who had a repeat biopsy, prostate cancer was detected in 20 patients. Of the 20, positive cores were detected in the transition zone in nine patients, including six patients who had positive biopsies only in the transition zone.

"There are no statistically significant differences in the prostate cancer detection rate between eight- and twelve-core prostate biopsy protocols. Transition zone biopsies contribute to prostate cancer detection in a repeat biopsy protocol," the authors write.

One study author reported financial relationships with three medical companies.

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Specialties Cardiology
Diabetes & Endocrinology
Internal Medicine
Family Practice

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