Friday, October 2, 2009
FRIDAY, Oct. 2 (HealthDay News) -- Transurethral prostate resection may be a useful addition to prostate biopsy in detecting cancer in men whose prostate-specific antigen (PSA) remains a concern after previous negative biopsies, according to research published in the October issue of the Journal of Urology.
Guillaume Ploussard, M.D., of the Centre Hospitalier Universitaire Henri Mondor in Creteil, France, and colleagues analyzed data from 113 patients who underwent transurethral resection of the prostate (TURP) along with a set of 21-core biopsies. All patients had persistently high or increasing PSA and had undergone at least two sets of extended 21-core negative biopsies.
The researchers found that prostate cancer was found in 27 men. Extended biopsy had an 18.6 percent detection rate, and TURP increased the detection rate by 28.5 percent, which was a significant increase compared to biopsy alone. Most cancers found in samples from TURP or biopsy were clinically significant.
"About a fourth of patients with two extended multi-site negative prostate biopsy sets remained at risk for prostate cancer and tumors undetected at initial procedures were not trivial. Repeating biopsy using general anesthesia increased the detection rate, which was 18.6 percent. The diagnostic yield of TURP was moderate but significant and may provide additional data of clinical importance in select patients. Patients may also benefit from the procedure because of decreased PSA during biological follow-up and better prostate sampling at subsequent biopsy sets," the authors conclude.
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