Cancer News
OncoLink Cancer News - HealthDay

Benefit of BRCA Testing in Ovarian Cancer Examined

-- Jeff Muise

Thursday, October 22, 2009

THURSDAY, Oct. 22 (HealthDay News) -- Testing women with ovarian cancer for the BRCA mutation if they have a personal history of breast cancer, a family history of breast or ovarian cancer, or are of Ashkenazi Jewish ancestry, is a cost-effective strategy that may prevent cancers in first degree relatives (FDR), according to a study published online Oct. 19 in the Journal of Clinical Oncology.

Janice S. Kwon, M.D., of the University of British Columbia in Vancouver, Canada, and colleagues developed a Markov Monte Carlo model to evaluate the benefits of BRCA testing. The researchers compared four testing criteria, including no testing; testing if the patient has a personal history of breast cancer, or a family history of ovarian or breast cancers; the patient is of Ashkenazi Jewish ancestry; and testing only if the patient has invasive serous cancer or any invasive non-mucinous epithelial cancer.

The researchers found that BRCA testing could prevent future cancers in FDRs with an incremental cost-effectiveness ratio (ICER) of $32,018 per year of life (LY) gained in women with a personal or family history or of Ashkenazi Jewish ancestry. Testing in cases of serous or any non-mucinous epithelial ovarian cancer would prevent additional cancer in FDRs, but at prohibitively high ICERs ($128,465 and $148,363 per LY gained, respectively).

"BRCA testing of women with ovarian cancer based on personal/family history of cancer or Ashkenazi Jewish ancestry is a cost-effective strategy to prevent future breast and ovarian cancers among FDRs. More inclusive testing strategies prevent additional cancer cases but at significant cost," the authors conclude.

Full Text (subscription or payment may be required)

Specialties Cardiology
Diabetes & Endocrinology
Internal Medicine
Family Practice

Copyright © 2009 ScoutNews, LLC. All rights reserved.

I Wish You Knew

Pain management in cancer care - are patients getting what they need?

View More

Blogs and Web Chats

OncoLink Blogs give our readers a chance to react to and comment on key cancer news topics and provides a forum for OncoLink Experts and readers to share opinions and learn from each other.

OncoLink OncoPilot

Facing a new cancer diagnosis or changing the course of your current treatment? Let our cancer nurses help you through!

Learn More