Increased rate likely due to rise in infections related to transrectal ultrasound-guided biopsy

-- Jeff Muise

Wednesday, March 17, 2010 (Last Updated: 03/18/2010)

WEDNESDAY, March 17 (HealthDay News) -- The rate of hospital admission after transrectal ultrasound-guided biopsy for suspected prostate cancer increased significantly between 1996 and 2005, primarily due to an increasing rate of post-procedure infection, according to a Canadian study in the March issue of The Journal of Urology.

Robert K. Nam, M.D., of the University of Toronto, and colleagues analyzed data from the Ontario Health Insurance Plan, the Canadian Institute of Health Information, the Ontario Cancer Registry, and other data sources on 75,190 men who underwent the biopsy procedure. The researchers estimated rates of 30-day hospital admission and mortality from biopsy complications, such as infection, bleeding, and urinary tract obstruction.

The researchers found that 44.6 percent of the men who underwent biopsy received a prostate cancer diagnosis and 55.4 percent did not. During the study period, complications leading to hospital admission occurred in 0.8 percent of men with a cancer diagnosis and 1.9 percent of men without. The admission rate exhibited an increase from 1.0 percent in 1996 to 4.1 percent in 2005, due primarily to an increase in the infection rate from 0.6 to 3.6 percent over the period. The overall 30-day mortality rate was 0.09 percent and did not show a trend.

"It is unclear why there is an increasing trend of hospital admission rates, particularly for infections. Men with underlying prostatitis which would prompt a prostate biopsy due to falsely increased prostate-specific antigen may have been predisposed to exacerbated infection requiring hospital admission," the authors write.

One author reported financial or other relationships with Abbott, AstraZeneca, Aventis, Merck and GlaxoSmithKline.

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Specialties Urology

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