Cancer News
OncoLink Cancer News - HealthDay


Variants altering expression of GPC5 may affect susceptibility to disease in non-smokers

-- Eric Metcalf

Thursday, March 25, 2010 (Last Updated: 03/26/2010)

THURSDAY, March 25 (HealthDay News) -- Genetic variants that affect the expression of the GPC5 gene may play a role in lung cancer in people who have never smoked, according to research published online March 22 in The Lancet Oncology.

Yafei Li, Ph.D., of the Mayo Clinic College of Medicine in Rochester, Minn., and colleagues analyzed data from a genome-wide association study of single nucleotide polymorphisms (SNPs) in a group of 754 cases and controls who were never smokers. Top candidate SNPs were validated in two more groups of never smokers, and the top SNP was further replicated in another group.

The researchers identified 44 top candidate SNPs. Using an additive genetic model in the four independent studies, they replicated rs2352028 at chromosome 13q31.3; there was a combined odds ratio of 1.46. Using a cis expression quantitative trait loci analysis, they found an association between the SNP genotypes and expression of GPC5 in normal lung tissue, with the high-risk allele linked to lower expression. The transcription level of GPC5 was twice as high in normal lung tissue than matched lung adenocarcinoma tissue.

"In summary, we have identified a genetic locus at 13q31.3 that regulates the expression of GPC5, which might contribute to the development of lung cancer in never smokers. Future studies are needed to investigate the regulatory effect of these SNPs (or tagged variants) and the functional role of GPC5 in lung tumorigenesis," the authors write.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Specialties Radiology
OBGYN & Women's Health
Oncology
Pathology

Copyright © 2010 HealthDay. All rights reserved.


I Wish You Knew

The culture of a patient is important

View More



Blogs and Web Chats

OncoLink Blogs give our readers a chance to react to and comment on key cancer news topics and provides a forum for OncoLink Experts and readers to share opinions and learn from each other.




OncoLink OncoPilot

Facing a new cancer diagnosis or changing the course of your current treatment? Let our cancer nurses help you through!

Learn More